Technology Process of 3-(2,3-dimethoxy-6-(1-oxo-1,3-dihydroisobenzofuran-5-yl)phenoxy)-N-isopropyl-2,2-dimethylpropanamide
There total 9 articles about 3-(2,3-dimethoxy-6-(1-oxo-1,3-dihydroisobenzofuran-5-yl)phenoxy)-N-isopropyl-2,2-dimethylpropanamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-(2,3-dimethoxy-6-(1-oxo-1,3-dihydroisobenzofuran-5-yl)phenoxy)-2,2-dimethylpropanoic acid;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
dichloromethane;
for 0.166667h;
isopropylamine;
In
dichloromethane;
at 20 ℃;
for 16h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: N-Bromosuccinimide / tetrahydrofuran / 1 h / 20 - 25 °C
2.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C
3.1: n-butyllithium / tetrahydrofuran / 0.33 h / -78 °C
3.2: 0.5 h / -78 °C
4.1: caesium carbonate / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 3 h / 70 °C / Inert atmosphere
5.1: hydrogenchloride; water / methanol / 0.25 h / 0 - 50 °C
6.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 6 h / 70 °C
7.1: water; lithium hydroxide / tetrahydrofuran / 4 h / 20 °C
7.2: pH 5
8.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 0.17 h
8.2: 16 h / 20 °C
With
hydrogenchloride; N-Bromosuccinimide; n-butyllithium; water; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; lithium hydroxide; diethylazodicarboxylate;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: n-butyllithium / tetrahydrofuran / 0.33 h / -78 °C
1.2: 0.5 h / -78 °C
2.1: caesium carbonate / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 3 h / 70 °C / Inert atmosphere
3.1: hydrogenchloride; water / methanol / 0.25 h / 0 - 50 °C
4.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 6 h / 70 °C
5.1: water; lithium hydroxide / tetrahydrofuran / 4 h / 20 °C
5.2: pH 5
6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 0.17 h
6.2: 16 h / 20 °C
With
hydrogenchloride; n-butyllithium; water; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; lithium hydroxide; diethylazodicarboxylate;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
