4-N-benzoyl-5'-O-(dimethoxytrityl)-3'-O-(tert-butyldimethylsilyl)-2'-deoxy-2'-mercaptocytidine

Base Information

Chemical Name:4-N-benzoyl-5'-O-(dimethoxytrityl)-3'-O-(tert-butyldimethylsilyl)-2'-deoxy-2'-mercaptocytidine
CAS No.:235773-85-0
Molecular Formula:C₄₃H₄₉N₃O₇SSi
Molecular Weight:780.029
Hs Code.:

Synonyms:4-N-benzoyl-5'-O-(dimethoxytrityl)-3'-O-(tert-butyldimethylsilyl)-2'-deoxy-2'-mercaptocytidine

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Chemical Property of 4-N-benzoyl-5'-O-(dimethoxytrityl)-3'-O-(tert-butyldimethylsilyl)-2'-deoxy-2'-mercaptocytidine

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Technology Process of 4-N-benzoyl-5'-O-(dimethoxytrityl)-3'-O-(tert-butyldimethylsilyl)-2'-deoxy-2'-mercaptocytidine

There total 4 articles about 4-N-benzoyl-5'-O-(dimethoxytrityl)-3'-O-(tert-butyldimethylsilyl)-2'-deoxy-2'-mercaptocytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 235773-84-9
4-N-benzoyl-5'-O-(dimethoxytrityl)-3'-O-(tert-butyldimethylsilyl)-2'-deoxy-2'-(2-pyridyldithio)cytidine

: 235773-85-0
4-N-benzoyl-5'-O-(dimethoxytrityl)-3'-O-(tert-butyldimethylsilyl)-2'-deoxy-2'-mercaptocytidine

Guidance literature:: With DL-dithiothreitol; TEA; In tetrahydrofuran; for 3h;
DOI:10.1021/jo9903508

Reference yield:

: 189869-59-8
4-N-benzoyl-2'-deoxy-2'-(tritylthio)cytidine

: 235773-85-0
4-N-benzoyl-5'-O-(dimethoxytrityl)-3'-O-(tert-butyldimethylsilyl)-2'-deoxy-2'-mercaptocytidine

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / AgNO₃ / CHCl₃; methanol / 2 h

2: 85 percent / DMAP / pyridine / 6 h

3: 86 percent / imidazole / pyridine / 24 h

4: 95 percent / DTT, TEA / tetrahydrofuran / 3 h

With 1H-imidazole; dmap; DL-dithiothreitol; TEA; silver nitrate; In tetrahydrofuran; pyridine; methanol; chloroform;
DOI:10.1021/jo9903508

Reference yield:

: 235773-75-8
4-N-benzoyl-2'-deoxy-2'-(2-pyridyldithio)cytidine

: 235773-85-0
4-N-benzoyl-5'-O-(dimethoxytrityl)-3'-O-(tert-butyldimethylsilyl)-2'-deoxy-2'-mercaptocytidine

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / DMAP / pyridine / 6 h

2: 86 percent / imidazole / pyridine / 24 h

3: 95 percent / DTT, TEA / tetrahydrofuran / 3 h

With 1H-imidazole; dmap; DL-dithiothreitol; TEA; In tetrahydrofuran; pyridine;
DOI:10.1021/jo9903508