3-[6-(3,4-dichlorophenylamino)pyrimidin-4-yl]-benzoic acid methyl ester

Base Information

• Chemical Name: 3-[6-(3,4-dichlorophenylamino)pyrimidin-4-yl]-benzoic acid methyl ester
• CAS No.: 1228298-37-0
• Molecular Formula: C₁₈H₁₃Cl₂N₃O₂
• Molecular Weight: 374.226
• Mol file: 1228298-37-0.mol

Synonyms:3-[6-(3,4-dichlorophenylamino)pyrimidin-4-yl]-benzoic acid methyl ester

Chemical Property of 3-[6-(3,4-dichlorophenylamino)pyrimidin-4-yl]-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 3-[6-(3,4-dichlorophenylamino)pyrimidin-4-yl]-benzoic acid methyl ester

There total 1 articles about 3-[6-(3,4-dichlorophenylamino)pyrimidin-4-yl]-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

(6-chloropyrimidin-4-yl)-(3,4-dichlorophenyl)-amine (6303-46-4) + [3-(methoxycarbonyl)phenyl]boronic acid (99769-19-4) → 3-[6-(3,4-dichlorophenylamino)pyrimidin-4-yl]-benzoic acid methyl ester (1228298-37-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,2-dimethoxyethane; ethanol; water; at 125 ℃; Microwave irradiation; Inert atmosphere;

DOI:10.1021/ja101837n

Reference yield:

3-[6-(3,4-dichlorophenylamino)pyrimidin-4-yl]-benzoic acid methyl ester (1228298-37-0) + formamide (77287-34-4,77287-35-5,60100-09-6) → C18H12Cl2N4O2

Guidance literature:

In N,N-dimethyl-formamide; at 100 ℃; for 0.0833333h;

DOI:10.1021/ja101837n

upstream raw materials:

(6-chloropyrimidin-4-yl)-(3,4-dichlorophenyl)-amine

[3-(methoxycarbonyl)phenyl]boronic acid