(R)-2-allyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethylheptanamide

Base Information

Chemical Name:(R)-2-allyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethylheptanamide
CAS No.:1068602-08-3
Molecular Formula:C₂₁H₃₃NO₂
Molecular Weight:331.499
Hs Code.:

Synonyms:(R)-2-allyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethylheptanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-allyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethylheptanamide

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Technology Process of (R)-2-allyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethylheptanamide

There total 2 articles about (R)-2-allyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethylheptanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 109-72-8,29786-93-4
n-butyllithium

: 1068601-67-1,38735-14-7
N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylmethacrylamide

: 106-95-6
allyl bromide

: (S)-2-allyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethylheptanamide

: 1068602-08-3
(R)-2-allyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethylheptanamide

: 90-82-4,7009-81-6,90-83-5,6912-63-6
pseudoephedrine

Guidance literature:: N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylmethacrylamide; With methyllithium; lithium chloride; In tetrahydrofuran; formaldehyde diethyl acetal; at -78 ℃; Inert atmosphere;

n-butyllithium; In tetrahydrofuran; formaldehyde diethyl acetal; hexane; at -78 - -40 ℃; Inert atmosphere;

allyl bromide; In tetrahydrofuran; formaldehyde diethyl acetal; hexane; at -40 ℃; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ja806021y

Reference yield:

: 109-72-8,29786-93-4
n-butyllithium

: 1068601-67-1,38735-14-7
N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylmethacrylamide

: 106-95-6
allyl bromide

: (S)-2-allyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethylheptanamide

: 1068602-08-3
(R)-2-allyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethylheptanamide

Guidance literature:: N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylmethacrylamide; With methyllithium; lithium chloride; In tetrahydrofuran; formaldehyde diethyl acetal; at -78 ℃; for 0.166667h; Inert atmosphere;

n-butyllithium; In tetrahydrofuran; formaldehyde diethyl acetal; hexane; at -78 - -40 ℃; for 0.333333h; Inert atmosphere;

allyl bromide; In tetrahydrofuran; formaldehyde diethyl acetal; hexane; at -40 ℃; for 3h; optical yield given as %de; Inert atmosphere;
DOI:10.1002/anie.201200370