4-formyl-1(R)-methyl-3(E)-butenyl (3R,4S,5S,6R,8R)-10-dimethoxyphosphono-3,5-isopropylidenedioxy-4-methoxy-6-<2-(4-methoxybenzyloxy)ethyl>-8-methyl-9-oxodecanoate

Base Information

Chemical Name:4-formyl-1(R)-methyl-3(E)-butenyl (3R,4S,5S,6R,8R)-10-dimethoxyphosphono-3,5-isopropylidenedioxy-4-methoxy-6-<2-(4-methoxybenzyloxy)ethyl>-8-methyl-9-oxodecanoate
CAS No.:129251-01-0
Molecular Formula:C₃₃H₅₁O₁₂P
Molecular Weight:670.734
Hs Code.:

4-formyl-1(R)-methyl-3(E)-butenyl (3R,4S,5S,6R,8R)-10-dimethoxyphosphono-3,5-isopropylidenedioxy-4-methoxy-6-<2-(4-methoxybenzyloxy)ethyl>-8-methyl-9-oxodecanoate

Synonyms:4-formyl-1(R)-methyl-3(E)-butenyl (3R,4S,5S,6R,8R)-10-dimethoxyphosphono-3,5-isopropylidenedioxy-4-methoxy-6-<2-(4-methoxybenzyloxy)ethyl>-8-methyl-9-oxodecanoate

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Chemical Property of 4-formyl-1(R)-methyl-3(E)-butenyl (3R,4S,5S,6R,8R)-10-dimethoxyphosphono-3,5-isopropylidenedioxy-4-methoxy-6-<2-(4-methoxybenzyloxy)ethyl>-8-methyl-9-oxodecanoate

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Technology Process of 4-formyl-1(R)-methyl-3(E)-butenyl (3R,4S,5S,6R,8R)-10-dimethoxyphosphono-3,5-isopropylidenedioxy-4-methoxy-6-<2-(4-methoxybenzyloxy)ethyl>-8-methyl-9-oxodecanoate

There total 7 articles about 4-formyl-1(R)-methyl-3(E)-butenyl (3R,4S,5S,6R,8R)-10-dimethoxyphosphono-3,5-isopropylidenedioxy-4-methoxy-6-<2-(4-methoxybenzyloxy)ethyl>-8-methyl-9-oxodecanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 69830-85-9
(-)-(5R)-hydroxy-(2E)-hexenal

: 129251-00-9
(3R,4S,5S,6R,8R)-10-dimethoxyphosphono-3,5-isopropylidenedioxy-4-methoxy-6-<2-(4-methoxybenzyloxy)ethyl>-8-methyl-9-oxodecanoic acid

: 129251-01-0
4-formyl-1(R)-methyl-3(E)-butenyl (3R,4S,5S,6R,8R)-10-dimethoxyphosphono-3,5-isopropylidenedioxy-4-methoxy-6-<2-(4-methoxybenzyloxy)ethyl>-8-methyl-9-oxodecanoate

Guidance literature:: With dmap; In toluene; for 1.5h; Ambient temperature;

Reference yield:

: 90941-89-2
(E)-4-((S)-2,2-Diethyl-[1,3]dioxolan-4-yl)-but-2-en-1-ol

: 129251-01-0
4-formyl-1(R)-methyl-3(E)-butenyl (3R,4S,5S,6R,8R)-10-dimethoxyphosphono-3,5-isopropylidenedioxy-4-methoxy-6-<2-(4-methoxybenzyloxy)ethyl>-8-methyl-9-oxodecanoate

Guidance literature:: Multi-step reaction with 7 steps

1: 1) NaH / 1) DMSO, THF, r.t, 1h, 2) 10h

2: 97 percent / 2percent H₂SO₄ / methanol / 4 h / Ambient temperature

3: 72 percent / pyridine / CH₂Cl₂ / 10 h / Ambient temperature

4: 92 percent / LiAlH₄ / diethyl ether / 0.67 h / 0 °C

5: 90 percent / DDQ, H₂O / CH₂Cl₂ / 0.67 h

6: 90 percent / active MnO₂ / CH₂Cl₂ / 1 h

7: 1) 2,4,6-trichlorobenzoyl chloride, Et₃N, 2) DMAP / 1) THF, r.t, 1h, 2) toluene, 1.5h

With pyridine; dmap; manganese(IV) oxide; lithium aluminium tetrahydride; sulfuric acid; 2,4,6-trichlorobenzoyl chloride; water; sodium hydride; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In methanol; diethyl ether; dichloromethane;
DOI:10.1248/cpb.39.64

Reference yield:

: 133839-50-6
(S)-2,2-Diethyl-4-[(E)-4-(4-methoxy-benzyloxy)-but-2-enyl]-[1,3]dioxolane

: 129251-01-0
4-formyl-1(R)-methyl-3(E)-butenyl (3R,4S,5S,6R,8R)-10-dimethoxyphosphono-3,5-isopropylidenedioxy-4-methoxy-6-<2-(4-methoxybenzyloxy)ethyl>-8-methyl-9-oxodecanoate

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / 2percent H₂SO₄ / methanol / 4 h / Ambient temperature

2: 72 percent / pyridine / CH₂Cl₂ / 10 h / Ambient temperature

3: 92 percent / LiAlH₄ / diethyl ether / 0.67 h / 0 °C

4: 90 percent / DDQ, H₂O / CH₂Cl₂ / 0.67 h

5: 90 percent / active MnO₂ / CH₂Cl₂ / 1 h

6: 1) 2,4,6-trichlorobenzoyl chloride, Et₃N, 2) DMAP / 1) THF, r.t, 1h, 2) toluene, 1.5h

With pyridine; dmap; manganese(IV) oxide; lithium aluminium tetrahydride; sulfuric acid; 2,4,6-trichlorobenzoyl chloride; water; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In methanol; diethyl ether; dichloromethane;
DOI:10.1248/cpb.39.64