2-((2R,3S)-3-methyl-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile

Base Information

Chemical Name:2-((2R,3S)-3-methyl-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile
CAS No.:1283146-03-1
Molecular Formula:C₂₁H₂₄N₂
Molecular Weight:304.435
Hs Code.:

Synonyms:2-((2R,3S)-3-methyl-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile

Suppliers and Price of 2-((2R,3S)-3-methyl-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 2-((2R,3S)-3-methyl-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-((2R,3S)-3-methyl-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile

There total 7 articles about 2-((2R,3S)-3-methyl-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1283146-02-0
((2S,3S)-3-methyl-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)methanol

: 75-86-5
2-hydroxy-2-methylpropanenitrile

: 1283146-03-1
2-((2R,3S)-3-methyl-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile

Guidance literature:: ((2S,3S)-3-methyl-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)methanol; With triphenylphosphine; diethylazodicarboxylate; In dichloromethane; for 0.25h;

2-hydroxy-2-methylpropanenitrile; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: C₁₆H₂₇NO₆

: 1283146-03-1
2-((2R,3S)-3-methyl-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate / water / 0 - 20 °C

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3: copper(l) iodide; sodium hydroxide / isopropyl alcohol / 90 °C / Inert atmosphere; Sealed tube

4: diethylazodicarboxylate; triphenylphosphine / dichloromethane / 3 h

With hydrogenchloride; sodium tetrahydroborate; copper(l) iodide; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; In 1,4-dioxane; dichloromethane; water; isopropyl alcohol;
DOI:10.1021/acs.jmedchem.6b01559

Reference yield:

: 817554-71-5
((2S,3S)-3-methylpyrrolidin-2-yl)methanol hydrochloride

: 1283146-03-1
2-((2R,3S)-3-methyl-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; sodium hydroxide / isopropyl alcohol / 90 °C / Inert atmosphere; Sealed tube

2: diethylazodicarboxylate; triphenylphosphine / dichloromethane / 3 h

With copper(l) iodide; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; In dichloromethane; isopropyl alcohol;
DOI:10.1021/acs.jmedchem.6b01559