(R)-4-(2-(hydroxymethyl)-5-oxopyrrolidin-1-yl)-3-methyl-2-(trifluoromethyl)benzonitrile

Base Information

Chemical Name:(R)-4-(2-(hydroxymethyl)-5-oxopyrrolidin-1-yl)-3-methyl-2-(trifluoromethyl)benzonitrile
CAS No.:1371608-77-3
Molecular Formula:C₁₄H₁₃F₃N₂O₂
Molecular Weight:298.265
Hs Code.:

Synonyms:(R)-4-(2-(hydroxymethyl)-5-oxopyrrolidin-1-yl)-3-methyl-2-(trifluoromethyl)benzonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-4-(2-(hydroxymethyl)-5-oxopyrrolidin-1-yl)-3-methyl-2-(trifluoromethyl)benzonitrile

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Technology Process of (R)-4-(2-(hydroxymethyl)-5-oxopyrrolidin-1-yl)-3-methyl-2-(trifluoromethyl)benzonitrile

There total 7 articles about (R)-4-(2-(hydroxymethyl)-5-oxopyrrolidin-1-yl)-3-methyl-2-(trifluoromethyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1371608-76-2
(R)-3-methyl-4-(2-oxo-5-((trityloxy)methyl)pyrrolidin-1-yl)-2-(trifluoromethyl)benzonitrile

: 1371608-77-3
(R)-4-(2-(hydroxymethyl)-5-oxopyrrolidin-1-yl)-3-methyl-2-(trifluoromethyl)benzonitrile

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 0 ℃; for 4h;

Reference yield:

: 13691-92-4
N-(4-chloro-3-trifluoromethylphenyl)-2,2-dimethylpropionamide

: 1371608-77-3
(R)-4-(2-(hydroxymethyl)-5-oxopyrrolidin-1-yl)-3-methyl-2-(trifluoromethyl)benzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran / 3 h / 0 °C

1.2: 3 h / 0 °C

2.1: 1-methyl-pyrrolidin-2-one / 36 h / 220 °C / Inert atmosphere

3.1: hydrogenchloride; ethanol / 12 h / 80 °C

4.1: sodium nitrite; hydrogen bromide / water / 0.17 h / 0 °C

4.2: 1 h / 0 - 50 °C

5.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 12 h / 80 °C / Inert atmosphere

6.1: hydrogenchloride / 1,4-dioxane / 4 h / 0 °C

With hydrogenchloride; n-butyllithium; ethanol; hydrogen bromide; caesium carbonate; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water;

Reference yield:

: 112641-23-3
N-(4-Chloro-2-methyl-3-trifluoromethylphenyl)-2,2-dimethyl-propionamide

: 1371608-77-3
(R)-4-(2-(hydroxymethyl)-5-oxopyrrolidin-1-yl)-3-methyl-2-(trifluoromethyl)benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1-methyl-pyrrolidin-2-one / 36 h / 220 °C / Inert atmosphere

2.1: hydrogenchloride; ethanol / 12 h / 80 °C

3.1: sodium nitrite; hydrogen bromide / water / 0.17 h / 0 °C

3.2: 1 h / 0 - 50 °C

4.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 12 h / 80 °C / Inert atmosphere

5.1: hydrogenchloride / 1,4-dioxane / 4 h / 0 °C

With hydrogenchloride; ethanol; hydrogen bromide; caesium carbonate; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water;