2-(4'-(((((2S)-1-((2S)-3-methyl-2-(((methyloxy)carbonyl)amino)butanoyl)-2-pyrrolidinyl)carbonyl)oxy)acetyl)-4-biphenylyl)-2-oxoethyl(3S)-8,8-difluoro-2-((2S)-3-methyl-2-(((methyloxy)carbonyl)amino)butanoyl)-2-azaspiro[4.5]dec-3-carboxylate

Base Information

Chemical Name:2-(4'-(((((2S)-1-((2S)-3-methyl-2-(((methyloxy)carbonyl)amino)butanoyl)-2-pyrrolidinyl)carbonyl)oxy)acetyl)-4-biphenylyl)-2-oxoethyl(3S)-8,8-difluoro-2-((2S)-3-methyl-2-(((methyloxy)carbonyl)amino)butanoyl)-2-azaspiro[4.5]dec-3-carboxylate
CAS No.:1272655-85-2
Molecular Formula:C₄₅H₅₆F₂N₄O₁₂
Molecular Weight:882.956
Hs Code.:

2-(4'-(((((2S)-1-((2S)-3-methyl-2-(((methyloxy)carbonyl)amino)butanoyl)-2-pyrrolidinyl)carbonyl)oxy)acetyl)-4-biphenylyl)-2-oxoethyl(3S)-8,8-difluoro-2-((2S)-3-methyl-2-(((methyloxy)carbonyl)amino)butanoyl)-2-azaspiro[4.5]dec-3-carboxylate

Synonyms:2-(4'-(((((2S)-1-((2S)-3-methyl-2-(((methyloxy)carbonyl)amino)butanoyl)-2-pyrrolidinyl)carbonyl)oxy)acetyl)-4-biphenylyl)-2-oxoethyl(3S)-8,8-difluoro-2-((2S)-3-methyl-2-(((methyloxy)carbonyl)amino)butanoyl)-2-azaspiro[4.5]dec-3-carboxylate

Suppliers and Price of 2-(4'-(((((2S)-1-((2S)-3-methyl-2-(((methyloxy)carbonyl)amino)butanoyl)-2-pyrrolidinyl)carbonyl)oxy)acetyl)-4-biphenylyl)-2-oxoethyl(3S)-8,8-difluoro-2-((2S)-3-methyl-2-(((methyloxy)carbonyl)amino)butanoyl)-2-azaspiro[4.5]dec-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(4'-(((((2S)-1-((2S)-3-methyl-2-(((methyloxy)carbonyl)amino)butanoyl)-2-pyrrolidinyl)carbonyl)oxy)acetyl)-4-biphenylyl)-2-oxoethyl(3S)-8,8-difluoro-2-((2S)-3-methyl-2-(((methyloxy)carbonyl)amino)butanoyl)-2-azaspiro[4.5]dec-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(4'-(((((2S)-1-((2S)-3-methyl-2-(((methyloxy)carbonyl)amino)butanoyl)-2-pyrrolidinyl)carbonyl)oxy)acetyl)-4-biphenylyl)-2-oxoethyl(3S)-8,8-difluoro-2-((2S)-3-methyl-2-(((methyloxy)carbonyl)amino)butanoyl)-2-azaspiro[4.5]dec-3-carboxylate

There total 9 articles about 2-(4'-(((((2S)-1-((2S)-3-methyl-2-(((methyloxy)carbonyl)amino)butanoyl)-2-pyrrolidinyl)carbonyl)oxy)acetyl)-4-biphenylyl)-2-oxoethyl(3S)-8,8-difluoro-2-((2S)-3-methyl-2-(((methyloxy)carbonyl)amino)butanoyl)-2-azaspiro[4.5]dec-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1272656-06-0
(3S)-8,8-difluoro-2-{N-[(methyloxy)carbonyl]-L-valyl}-2-azaspiro[4.5]decane-3-carboxylic acid

: C₂₈H₃₁BrN₂O₇

: 1272655-85-2
2-(4'-(((((2S)-1-((2S)-3-methyl-2-(((methyloxy)carbonyl)amino)butanoyl)-2-pyrrolidinyl)carbonyl)oxy)acetyl)-4-biphenylyl)-2-oxoethyl(3S)-8,8-difluoro-2-((2S)-3-methyl-2-(((methyloxy)carbonyl)amino)butanoyl)-2-azaspiro[4.5]dec-3-carboxylate

Guidance literature:: With triethylamine; In acetonitrile; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1272655-96-5
3-ethyl 2-(phenylmethyl) 8-hydroxy-2-azaspiro[4.5]decane-2,3-dicarboxylate

: 1272655-85-2
2-(4'-(((((2S)-1-((2S)-3-methyl-2-(((methyloxy)carbonyl)amino)butanoyl)-2-pyrrolidinyl)carbonyl)oxy)acetyl)-4-biphenylyl)-2-oxoethyl(3S)-8,8-difluoro-2-((2S)-3-methyl-2-(((methyloxy)carbonyl)amino)butanoyl)-2-azaspiro[4.5]dec-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: Dess-Martin periodane / dichloromethane / 18 h / 20 °C / Inert atmosphere

2.1: ethanol; (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 2.5 h / 20 °C / Inert atmosphere

2.2: 18 h / Inert atmosphere

3.1: hydrogen / 10 wt% Pd(OH)2 on carbon / ethanol / 18 h / 3102.97 Torr

4.1: triethylamine; HATU / dichloromethane / 1 h / 20 °C / Inert atmosphere

4.2: 0.5 h / 20 °C

5.1: triethylamine / acetonitrile / 1 h / 20 °C / Inert atmosphere

With ethanol; hydrogen; Dess-Martin periodane; triethylamine; HATU; (bis-(2-methoxyethyl)amino)sulfur trufluoride; 10 wt% Pd(OH)2 on carbon; In ethanol; dichloromethane; acetonitrile;

Reference yield:

: 1272655-98-7
3-ethyl 2-(phenylmethyl)-8-oxo-2-azaspiro[4.5]decane-2,3-dicarboxylate

: 1272655-85-2
2-(4'-(((((2S)-1-((2S)-3-methyl-2-(((methyloxy)carbonyl)amino)butanoyl)-2-pyrrolidinyl)carbonyl)oxy)acetyl)-4-biphenylyl)-2-oxoethyl(3S)-8,8-difluoro-2-((2S)-3-methyl-2-(((methyloxy)carbonyl)amino)butanoyl)-2-azaspiro[4.5]dec-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol; (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 2.5 h / 20 °C / Inert atmosphere

1.2: 18 h / Inert atmosphere

2.1: hydrogen / 10 wt% Pd(OH)2 on carbon / ethanol / 18 h / 3102.97 Torr

3.1: triethylamine; HATU / dichloromethane / 1 h / 20 °C / Inert atmosphere

3.2: 0.5 h / 20 °C

4.1: triethylamine / acetonitrile / 1 h / 20 °C / Inert atmosphere

With ethanol; hydrogen; triethylamine; HATU; (bis-(2-methoxyethyl)amino)sulfur trufluoride; 10 wt% Pd(OH)2 on carbon; In ethanol; dichloromethane; acetonitrile;