2-fluoro-4-pent-1'-yn-1'-ylbenzonitrile

Base Information

Chemical Name:2-fluoro-4-pent-1'-yn-1'-ylbenzonitrile
CAS No.:123843-60-7
Molecular Formula:C₁₂H₁₀FN
Molecular Weight:187.217
Hs Code.:

Synonyms:2-fluoro-4-pent-1'-yn-1'-ylbenzonitrile

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Chemical Property of 2-fluoro-4-pent-1'-yn-1'-ylbenzonitrile

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Technology Process of 2-fluoro-4-pent-1'-yn-1'-ylbenzonitrile

There total 3 articles about 2-fluoro-4-pent-1'-yn-1'-ylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 627-19-0
1-Pentyne

: 105942-08-3
4-bromo-6-fluorobenzonitrile

: 123843-60-7
2-fluoro-4-pent-1'-yn-1'-ylbenzonitrile

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; zinc(II) chloride; In tetrahydrofuran; hexane; for 20h; Ambient temperature;

Reference yield:

: 348-54-9
2-Fluoroaniline

: 123843-60-7
2-fluoro-4-pent-1'-yn-1'-ylbenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / N-bromosuccinimide / CH₂Cl₂ / 45 h / 0 °C

2: 76 percent / 1.) cc. sulphuric acid, sodium nitrite, 2.) copper(II) sulphate pentahydrate, sodium hydrogen carbonate / H₂O; acetic acid; cyclohexane / 1.) -5 deg C, 15 min; 2.) 50 deg C

3: 94 percent / n-butyllithium, zinc chloride, tetrakis(triphenylphosphine)palladium⁽⁰⁾ / hexane; tetrahydrofuran / 20 h / Ambient temperature

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sulfuric acid; sodium hydrogencarbonate; copper(II) sulfate; zinc(II) chloride; sodium nitrite; In tetrahydrofuran; hexane; dichloromethane; cyclohexane; water; acetic acid;

Reference yield:

: 367-24-8
4-bromo-2-fluoroaniline

: 123843-60-7
2-fluoro-4-pent-1'-yn-1'-ylbenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / 1.) cc. sulphuric acid, sodium nitrite, 2.) copper(II) sulphate pentahydrate, sodium hydrogen carbonate / H₂O; acetic acid; cyclohexane / 1.) -5 deg C, 15 min; 2.) 50 deg C

2: 94 percent / n-butyllithium, zinc chloride, tetrakis(triphenylphosphine)palladium⁽⁰⁾ / hexane; tetrahydrofuran / 20 h / Ambient temperature

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sulfuric acid; sodium hydrogencarbonate; copper(II) sulfate; zinc(II) chloride; sodium nitrite; In tetrahydrofuran; hexane; cyclohexane; water; acetic acid;