2-[({5-(2,6-dimethoxyphenyl)-1-[4-({[3-({4-[1-(2-deoxy-2-fluoro-β-D-glucopyranosyl)-1H-1,2,3-triazole-4-yl]butyl}(methyl)amino)propyl](methyl)amino}carbonyl)-2-isopropylphenyl]-1Hpyrazole-3-yl}carbonyl)amino]adamantane-2-carboxylic acid

Base Information

Chemical Name:2-[({5-(2,6-dimethoxyphenyl)-1-[4-({[3-({4-[1-(2-deoxy-2-fluoro-β-D-glucopyranosyl)-1H-1,2,3-triazole-4-yl]butyl}(methyl)amino)propyl](methyl)amino}carbonyl)-2-isopropylphenyl]-1Hpyrazole-3-yl}carbonyl)amino]adamantane-2-carboxylic acid
CAS No.:1476064-47-7
Molecular Formula:C₅₀H₆₇FN₈O₁₀
Molecular Weight:959.128
Hs Code.:

2-[({5-(2,6-dimethoxyphenyl)-1-[4-({[3-({4-[1-(2-deoxy-2-fluoro-β-D-glucopyranosyl)-1H-1,2,3-triazole-4-yl]butyl}(methyl)amino)propyl](methyl)amino}carbonyl)-2-isopropylphenyl]-1Hpyrazole-3-yl}carbonyl)amino]adamantane-2-carboxylic acid

Synonyms:2-[({5-(2,6-dimethoxyphenyl)-1-[4-({[3-({4-[1-(2-deoxy-2-fluoro-β-D-glucopyranosyl)-1H-1,2,3-triazole-4-yl]butyl}(methyl)amino)propyl](methyl)amino}carbonyl)-2-isopropylphenyl]-1Hpyrazole-3-yl}carbonyl)amino]adamantane-2-carboxylic acid

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Chemical Property of 2-[({5-(2,6-dimethoxyphenyl)-1-[4-({[3-({4-[1-(2-deoxy-2-fluoro-β-D-glucopyranosyl)-1H-1,2,3-triazole-4-yl]butyl}(methyl)amino)propyl](methyl)amino}carbonyl)-2-isopropylphenyl]-1Hpyrazole-3-yl}carbonyl)amino]adamantane-2-carboxylic acid

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Technology Process of 2-[({5-(2,6-dimethoxyphenyl)-1-[4-({[3-({4-[1-(2-deoxy-2-fluoro-β-D-glucopyranosyl)-1H-1,2,3-triazole-4-yl]butyl}(methyl)amino)propyl](methyl)amino}carbonyl)-2-isopropylphenyl]-1Hpyrazole-3-yl}carbonyl)amino]adamantane-2-carboxylic acid

There total 5 articles about 2-[({5-(2,6-dimethoxyphenyl)-1-[4-({[3-({4-[1-(2-deoxy-2-fluoro-β-D-glucopyranosyl)-1H-1,2,3-triazole-4-yl]butyl}(methyl)amino)propyl](methyl)amino}carbonyl)-2-isopropylphenyl]-1Hpyrazole-3-yl}carbonyl)amino]adamantane-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1159265-95-8
2-deoxy-2-fluoro-β-D-glucopyranosyl azide

: 1476064-49-9
2-({[5-(2,6-dimethoxyphenyl)-1-(4-{[{3-[hex-5-yn-1-yl(methyl)amino]propyl}(methyl)amino]carbonyl}-2-isopropylphenyl)-1H-pyrazole-3-yl]carbonyl}amino)adamantane-2-carboxylic acid

: 1476064-47-7
2-[({5-(2,6-dimethoxyphenyl)-1-[4-({[3-({4-[1-(2-deoxy-2-fluoro-β-D-glucopyranosyl)-1H-1,2,3-triazole-4-yl]butyl}(methyl)amino)propyl](methyl)amino}carbonyl)-2-isopropylphenyl]-1Hpyrazole-3-yl}carbonyl)amino]adamantane-2-carboxylic acid

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 20 ℃; for 72h;
DOI:10.1021/jm401491e

Reference yield:

: (6-chlorohex-1-yn-1-yl)triisopropylsilane

: 1476064-47-7
2-[({5-(2,6-dimethoxyphenyl)-1-[4-({[3-({4-[1-(2-deoxy-2-fluoro-β-D-glucopyranosyl)-1H-1,2,3-triazole-4-yl]butyl}(methyl)amino)propyl](methyl)amino}carbonyl)-2-isopropylphenyl]-1Hpyrazole-3-yl}carbonyl)amino]adamantane-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium iodide; potassium carbonate / acetonitrile / 71 h / Reflux

2: trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); tri tert-butylphosphoniumtetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,4-dioxane / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

4: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 72 h / 20 °C

With copper(ll) sulfate pentahydrate; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); tetrabutyl ammonium fluoride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium L-ascorbate; potassium iodide; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jm401491e

Reference yield:

: 1476064-43-3
N,N'-dimethyl-N-[6-(triisopropylsilyl)hex-5-ynyl]propane-1,3-diamine

: 1476064-47-7
2-[({5-(2,6-dimethoxyphenyl)-1-[4-({[3-({4-[1-(2-deoxy-2-fluoro-β-D-glucopyranosyl)-1H-1,2,3-triazole-4-yl]butyl}(methyl)amino)propyl](methyl)amino}carbonyl)-2-isopropylphenyl]-1Hpyrazole-3-yl}carbonyl)amino]adamantane-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); tri tert-butylphosphoniumtetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,4-dioxane / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

3: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 72 h / 20 °C

With copper(ll) sulfate pentahydrate; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); tetrabutyl ammonium fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium L-ascorbate; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; 1,4-dioxane; water; tert-butyl alcohol;
DOI:10.1021/jm401491e