4(1H)-Pyrimidinone, 2,5-diamino- (9CI)

Base Information

• Chemical Name: 4(1H)-Pyrimidinone, 2,5-diamino- (9CI)
• CAS No.: 77994-12-8
• Molecular Formula: C4H6 N4 O
• Molecular Weight: 126.118
• Hs Code.: 2933599090
• Mol file: 77994-12-8.mol

Synonyms:4(1H)-Pyrimidinone, 2,5-diamino- (9CI)

Chemical Property of 4(1H)-Pyrimidinone, 2,5-diamino- (9CI)

Chemical Property:

• PSA: 98.78000
• LogP: -0.14210
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

NLT 98% ^*data from raw suppliers

2,5-Diaminopyrimidin-4(3H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4(1H)-Pyrimidinone, 2,5-diamino- (9CI)

There total 5 articles about 4(1H)-Pyrimidinone, 2,5-diamino- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-amino-5-nitropyrimidin-4(3H)-one (7254-29-7) → 2,5-diaminopyrimidin-4(3H)-one (77994-12-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; water; at 20 ℃; for 3h; under 2844.39 Torr;

DOI:10.1002/anie.200603209

Reference yield:

5-chloro-2-phenyloxazolo[5,4-d]pyrimidine (118726-33-3) → 2,5-diaminopyrimidin-4(3H)-one (77994-12-8) + 8-phenyl-7(9)H-purin-2-ylamine

Guidance literature:

With ethanol; ammonia; at 160 ℃;

DOI:10.1021/ja01139a049

Reference yield:

→ 2,5-diaminopyrimidin-4(3H)-one (77994-12-8)

Guidance literature:

With ammonia; at 200 - 205 ℃; im Rohr;

upstream raw materials:

5-chloro-2-phenyloxazolo[5,4-d]pyrimidine

2-amino-5-nitropyrimidin-4(3H)-one

Refernces

• 1、 Mittapalli, Gopi Kumar,Osornio, Yazmin M.,Guerrero, Miguel A.,Reddy, Kondreddi Ravinder,Krishnamurthy, Ramanarayanan,Eschenmoser, Albert. "Mapping the landscape of potentially primordial informational oligomers: Oligodipeptides tagged with 2,4-disubstituted 5-aminopyrimidines as recognition elements". . p. 2478 - 2484. Retrieved 2008/03/11.