(5-IODO-PYRIDIN-2-YL)-HYDRAZINE

Base Information

• Chemical Name: (5-IODO-PYRIDIN-2-YL)-HYDRAZINE
• CAS No.: 77992-46-2
• Molecular Formula: C5H6 I N3
• Molecular Weight: 235.027
• Hs Code.: 2933990090
• Mol file: 77992-46-2.mol

Synonyms:2(1H)-Pyridinone,5-iodo-, hydrazone (9CI); 2-Hydrazino-5-iodopyridine;2-Hydrazinyl-5-iodopyridine

Chemical Property of (5-IODO-PYRIDIN-2-YL)-HYDRAZINE

Chemical Property:

• PSA: 50.94000
• LogP: 1.74510

Purity/Quality:

99% ^*data from raw suppliers

2-Hydrazino-5-iodopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (5-IODO-PYRIDIN-2-YL)-HYDRAZINE

There total 5 articles about (5-IODO-PYRIDIN-2-YL)-HYDRAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-choro-5-iodopyridine (69045-79-0) → (5-iodopyridin-2-yl)hydrazine (77992-46-2)

Guidance literature:

With pyridine; hydrazine hydrate; for 16h; Reflux;

DOI:10.1021/acs.jmedchem.5b01605

Reference yield: 90.0%

2-bromo-5-iodo-pyridine (73290-22-9) → (5-iodopyridin-2-yl)hydrazine (77992-46-2)

Guidance literature:

With hydrazine hydrate; In isopropyl alcohol; Reflux;

DOI:10.1002/jhet.2865

Reference yield:

2-aminopyridine (504-29-0) → (5-iodopyridin-2-yl)hydrazine (77992-46-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: iodine; sulfuric acid; sodium periodate; acetic acid / water / 4 h / 80 °C

2.1: hydrogen bromide / water / 10 °C / Heating

2.2: 0 - 10 °C

2.3: 1.5 h / 0 - 5 °C

3.1: hydrazine hydrate / isopropyl alcohol / Reflux

With sodium periodate; sulfuric acid; hydrogen bromide; iodine; hydrazine hydrate; acetic acid; In water; isopropyl alcohol;

DOI:10.1002/jhet.2865

upstream raw materials:

2-choro-5-iodopyridine

2-aminopyridine

2-amino-5-iodopyridine

2-bromo-5-iodo-pyridine

Downstream raw materials:

N-(5-iodo-pyridin-2-yl)-N'-[1-[3-(2-morpholin-4-yl-ethoxy)-phenyl]-meth-(E)-ylidene]-hydrazine

6-iodo-3,3-difluoro-2-(4-(thiophen-2-yl)benzylidene)-2,3-dihydro-[1,2,4,3]triazaborolo[4,5-a]pyridin-2-ium-3-uide

6-(4-(2-amino-3-((4-methoxyphenyl)diphenylmethylthio)-propanamido)but-1-ynyl)-3,3-difluoro-2-(propan-2-ylidene)-2,3-dihydro[1,2,4,3]triazaborolo[4,5-a]pyridin-2-ium-3-uide

5-iodo-2-(2-(4-(thiophen-2-yl)benzylidene)hydrazinyl)pyridine