1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)urea hydrochloride

Base Information

Chemical Name:1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)urea hydrochloride
CAS No.:1188906-56-0
Molecular Formula:C₂₄H₂₅N₅O₅*ClH
Molecular Weight:499.954
Hs Code.:

Synonyms:1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)urea hydrochloride

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Chemical Property of 1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)urea hydrochloride

Chemical Property:

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Technology Process of 1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)urea hydrochloride

There total 5 articles about 1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)urea hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1188906-54-8
1-(5-tert-butylisoxazol-3-yl)-3-(3-(6_,7-dimethoxyquinazolin-4-yloxy)phenyl)urea

: 1188906-56-0
1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)urea hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; ethyl acetate; Sonication;

Reference yield:

: 1188906-54-8
1-(5-tert-butylisoxazol-3-yl)-3-(3-(6_,7-dimethoxyquinazolin-4-yloxy)phenyl)urea

: 13790-39-1
6,7-dimethoxy-4-chloroquinazoline

: 1188906-56-0
1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)urea hydrochloride

Guidance literature:: 1-(5-tert-butylisoxazol-3-yl)-3-(3-(6_,7-dimethoxyquinazolin-4-yloxy)phenyl)urea; With hydrogenchloride; In 1,4-dioxane; ethyl acetate; Sonication;

6,7-dimethoxy-4-chloroquinazoline; With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 72h;
DOI:10.1016/j.bmcl.2011.07.019

Reference yield:

: 591-27-5
m-Hydroxyaniline

: 1188906-56-0
1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)urea hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: 50 °C

2.1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C

2.2: 72 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane; ethyl acetate / Sonication

3.2: 72 h / 20 °C

With hydrogenchloride; potassium tert-butylate; In tetrahydrofuran; 1,4-dioxane; ethyl acetate;
DOI:10.1016/j.bmcl.2011.07.019