(trans-4-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetonitrile hydrochloride

Base Information

Chemical Name:(trans-4-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetonitrile hydrochloride
CAS No.:1607590-16-8
Molecular Formula:C₁₈H₂₀N₄OS*ClH
Molecular Weight:376.91
Hs Code.:

Synonyms:(trans-4-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetonitrile hydrochloride

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Chemical Property of (trans-4-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetonitrile hydrochloride

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Technology Process of (trans-4-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetonitrile hydrochloride

There total 14 articles about (trans-4-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetonitrile hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

: 1607589-82-1
(trans-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetonitrile

: 1607590-16-8
(trans-4-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetonitrile hydrochloride

Guidance literature:: With hydrogenchloride; In water; acetonitrile; at 20 ℃;

Reference yield:

: 69627-02-7,107818-20-2
thieno[3,2-b]pyridin-7-ol

: 1607590-16-8
(trans-4-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetonitrile hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrabutylammonium nitrate / dichloromethane / -5 °C

1.2: -5 - 20 °C

2.1: trichlorophosphate / 1 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 90 °C

4.1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C

5.1: triethyloxonium fluoroborate / tetrahydrofuran / 1 h

5.2: 2 h / Reflux

6.1: hydrogenchloride / water; acetonitrile / 20 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; triethyloxonium fluoroborate; tetrabutylammonium nitrate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; water; isopropyl alcohol; acetonitrile;

Reference yield:

: 104515-05-1,905735-40-2
6-nitrothieno[3,2-b]pyridin-7-ol

: 1607590-16-8
(trans-4-{2-[(1R)-1-Hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)acetonitrile hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / 1 h / Reflux

2.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 2 h / 90 °C

3.1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C

4.1: triethyloxonium fluoroborate / tetrahydrofuran / 1 h

4.2: 2 h / Reflux

5.1: hydrogenchloride / water; acetonitrile / 20 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; triethyloxonium fluoroborate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; methanol; water; isopropyl alcohol; acetonitrile;