thiophene-2-carboxylic acid benzyl-{3-[4-(2-tert-butylsulfamoyl-5-isobutyl-thiophen-3-yl)-benzyl]-4-oxo-2-propyl-3,4-dihydro-quinazolin-6-yl}-amide

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Chemical Name:thiophene-2-carboxylic acid benzyl-{3-[4-(2-tert-butylsulfamoyl-5-isobutyl-thiophen-3-yl)-benzyl]-4-oxo-2-propyl-3,4-dihydro-quinazolin-6-yl}-amide
CAS No.:678144-98-4
Molecular Formula:C₄₂H₄₆N₄O₄S₃
Molecular Weight:767.05
Hs Code.:

thiophene-2-carboxylic acid benzyl-{3-[4-(2-<i>tert</i>-butylsulfamoyl-5-isobutyl-thiophen-3-yl)-benzyl]-4-oxo-2-propyl-3,4-dihydro-quinazolin-6-yl}-amide

Synonyms:thiophene-2-carboxylic acid benzyl-{3-[4-(2-tert-butylsulfamoyl-5-isobutyl-thiophen-3-yl)-benzyl]-4-oxo-2-propyl-3,4-dihydro-quinazolin-6-yl}-amide

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Chemical Property of thiophene-2-carboxylic acid benzyl-{3-[4-(2-tert-butylsulfamoyl-5-isobutyl-thiophen-3-yl)-benzyl]-4-oxo-2-propyl-3,4-dihydro-quinazolin-6-yl}-amide

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Technology Process of thiophene-2-carboxylic acid benzyl-{3-[4-(2-tert-butylsulfamoyl-5-isobutyl-thiophen-3-yl)-benzyl]-4-oxo-2-propyl-3,4-dihydro-quinazolin-6-yl}-amide

There total 6 articles about thiophene-2-carboxylic acid benzyl-{3-[4-(2-tert-butylsulfamoyl-5-isobutyl-thiophen-3-yl)-benzyl]-4-oxo-2-propyl-3,4-dihydro-quinazolin-6-yl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 5271-67-0
2-Thiophenecarbonyl chloride

: 678144-89-3
3-(4-{[6-(benzylamino)-4-oxo-2-propyl-3,4-dihydroquinazolin-3-yl]methyl}phenyl)-N-tert-butyl-5-isobutylthiophene-2-sulfonamide

: 678144-98-4
thiophene-2-carboxylic acid benzyl-{3-[4-(2-tert-butylsulfamoyl-5-isobutyl-thiophen-3-yl)-benzyl]-4-oxo-2-propyl-3,4-dihydro-quinazolin-6-yl}-amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/jm031031i

Reference yield:

: 156483-24-8
3-(4-bromobenzyl)-6-nitro-2-propyl-3,4-dihydroquinazolin-4-one

: 678144-98-4
thiophene-2-carboxylic acid benzyl-{3-[4-(2-tert-butylsulfamoyl-5-isobutyl-thiophen-3-yl)-benzyl]-4-oxo-2-propyl-3,4-dihydro-quinazolin-6-yl}-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 82 percent / [Pd(Ph₃)4]; NaOH / ethanol; toluene; H₂O / 2 h / 100 °C

2.1: 92 percent / HCO₂NH₄ / Pd/C / methanol / 2.5 h

3.1: acetic acid / 1,2-dichloro-ethane / 0.5 h

3.2: 95 percent / NaB(OAc)3H / 1,2-dichloro-ethane

4.1: 86 percent / DIEA / CH₂Cl₂ / 20 °C

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium formate; acetic acid; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane; toluene; 1.1: Suzuki coupling;
DOI:10.1021/jm031031i

Reference yield:

: 163520-14-7
5-isobutyl-2 -(tert-butylaminosulfonyl)-3-thiopheneboronic acid

: 678144-98-4
thiophene-2-carboxylic acid benzyl-{3-[4-(2-tert-butylsulfamoyl-5-isobutyl-thiophen-3-yl)-benzyl]-4-oxo-2-propyl-3,4-dihydro-quinazolin-6-yl}-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 82 percent / [Pd(Ph₃)4]; NaOH / ethanol; toluene; H₂O / 2 h / 100 °C

2.1: 92 percent / HCO₂NH₄ / Pd/C / methanol / 2.5 h

3.1: acetic acid / 1,2-dichloro-ethane / 0.5 h

3.2: 95 percent / NaB(OAc)3H / 1,2-dichloro-ethane

4.1: 86 percent / DIEA / CH₂Cl₂ / 20 °C

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium formate; acetic acid; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane; toluene; 1.1: Suzuki coupling;
DOI:10.1021/jm031031i