N-[(2S)-3-(3-{(2R)-2-[(tert-butoxycarbonyl)amino]propyl}phenyl)-2-methylpropanoyl]-L-alanyl-N-[(1R)-3-tert-butoxy-1-(4-methoxyphenyl)-3-oxopropyl]-N-methyl-D-tryptophanamide

Base Information

Chemical Name:N-[(2S)-3-(3-{(2R)-2-[(tert-butoxycarbonyl)amino]propyl}phenyl)-2-methylpropanoyl]-L-alanyl-N-[(1R)-3-tert-butoxy-1-(4-methoxyphenyl)-3-oxopropyl]-N-methyl-D-tryptophanamide
CAS No.:873326-29-5
Molecular Formula:C₄₇H₆₃N₅O₈
Molecular Weight:826.046
Hs Code.:

N-[(2S)-3-(3-{(2R)-2-[(tert-butoxycarbonyl)amino]propyl}phenyl)-2-methylpropanoyl]-L-alanyl-N-[(1R)-3-tert-butoxy-1-(4-methoxyphenyl)-3-oxopropyl]-N-methyl-D-tryptophanamide

Synonyms:N-[(2S)-3-(3-{(2R)-2-[(tert-butoxycarbonyl)amino]propyl}phenyl)-2-methylpropanoyl]-L-alanyl-N-[(1R)-3-tert-butoxy-1-(4-methoxyphenyl)-3-oxopropyl]-N-methyl-D-tryptophanamide

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Chemical Property of N-[(2S)-3-(3-{(2R)-2-[(tert-butoxycarbonyl)amino]propyl}phenyl)-2-methylpropanoyl]-L-alanyl-N-[(1R)-3-tert-butoxy-1-(4-methoxyphenyl)-3-oxopropyl]-N-methyl-D-tryptophanamide

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Technology Process of N-[(2S)-3-(3-{(2R)-2-[(tert-butoxycarbonyl)amino]propyl}phenyl)-2-methylpropanoyl]-L-alanyl-N-[(1R)-3-tert-butoxy-1-(4-methoxyphenyl)-3-oxopropyl]-N-methyl-D-tryptophanamide

There total 21 articles about N-[(2S)-3-(3-{(2R)-2-[(tert-butoxycarbonyl)amino]propyl}phenyl)-2-methylpropanoyl]-L-alanyl-N-[(1R)-3-tert-butoxy-1-(4-methoxyphenyl)-3-oxopropyl]-N-methyl-D-tryptophanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 873326-05-7
(2S)-3-(3-{(2S)-2-[(tert-butoxycarbonyl)amino]propyl}phenyl)-2-methylpropanoic acid

: 873326-33-1
L-alanyl-N-[(1R)-3-tert-butoxy-1-(4-methoxyphenyl)-3-oxopropyl]-N-methyl-D-tryptophanamide

: 873326-29-5
N-[(2S)-3-(3-{(2R)-2-[(tert-butoxycarbonyl)amino]propyl}phenyl)-2-methylpropanoyl]-L-alanyl-N-[(1R)-3-tert-butoxy-1-(4-methoxyphenyl)-3-oxopropyl]-N-methyl-D-tryptophanamide

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at -20 - 23 ℃; for 18.5h;
DOI:10.1002/chem.200500319

Reference yield:

: 873326-22-8
tert-butyl (3R)-3-amino-3-(4-methoxyphenyl)propanoate

: 873326-29-5
N-[(2S)-3-(3-{(2R)-2-[(tert-butoxycarbonyl)amino]propyl}phenyl)-2-methylpropanoyl]-L-alanyl-N-[(1R)-3-tert-butoxy-1-(4-methoxyphenyl)-3-oxopropyl]-N-methyl-D-tryptophanamide

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / HOBt; DCC / tetrahydrofuran / 12 h / 0 °C

2: 2,6-lutidine / CH₂Cl₂ / 1 h / 0 °C

3: 0.057 g / H₂O

4: 60 percent / HOBt; DCC / tetrahydrofuran / 18.5 h / -20 - 23 °C

With 2,6-dimethylpyridine; water; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1002/chem.200500319

Reference yield:

: 3-isocyanato-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester

: 873326-29-5
N-[(2S)-3-(3-{(2R)-2-[(tert-butoxycarbonyl)amino]propyl}phenyl)-2-methylpropanoyl]-L-alanyl-N-[(1R)-3-tert-butoxy-1-(4-methoxyphenyl)-3-oxopropyl]-N-methyl-D-tryptophanamide

Guidance literature:: Multi-step reaction with 6 steps

1: 0.61 g / toluene / 3 h / Heating

2: 60 percent / Et₂NH / tetrahydrofuran / 12 h / 23 °C

3: 96 percent / HOBt; DCC / tetrahydrofuran / 12 h / 0 °C

4: 2,6-lutidine / CH₂Cl₂ / 1 h / 0 °C

5: 0.057 g / H₂O

6: 60 percent / HOBt; DCC / tetrahydrofuran / 18.5 h / -20 - 23 °C

With 2,6-dimethylpyridine; water; benzotriazol-1-ol; diethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1002/chem.200500319