(R)-3-chloro-2-[2-chloro-5-(5-oxo-pyrrolidin-3-yl)-phenoxy]-benzonitrile

Base Information

• Chemical Name: (R)-3-chloro-2-[2-chloro-5-(5-oxo-pyrrolidin-3-yl)-phenoxy]-benzonitrile
• CAS No.: 903578-43-8
• Molecular Formula: C₁₇H₁₂Cl₂N₂O₂
• Molecular Weight: 347.2
• Mol file: 903578-43-8.mol

Synonyms:(R)-3-chloro-2-[2-chloro-5-(5-oxo-pyrrolidin-3-yl)-phenoxy]-benzonitrile

Chemical Property of (R)-3-chloro-2-[2-chloro-5-(5-oxo-pyrrolidin-3-yl)-phenoxy]-benzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-chloro-2-[2-chloro-5-(5-oxo-pyrrolidin-3-yl)-phenoxy]-benzonitrile

There total 1 articles about (R)-3-chloro-2-[2-chloro-5-(5-oxo-pyrrolidin-3-yl)-phenoxy]-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-4-(4-chloro-3-hydroxy-phenyl)-pyrrolidin-2-one + 3-chloro-2-fluorobenzonitrile (94087-40-8) → (R)-3-chloro-2-[2-chloro-5-(5-oxo-pyrrolidin-3-yl)-phenoxy]-benzonitrile (903578-43-8)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 24h;

Reference yield:

(R)-3-chloro-2-[2-chloro-5-(5-oxo-pyrrolidin-3-yl)-phenoxy]-benzonitrile (903578-43-8) + 5-iodo-2-[methanesulfonyl-(4-methoxy-benzyl)-amino]-N,N-bis-(4-methoxy-benzyl)-benzamide (903578-45-0) → C49H44Cl2N4O8S

Guidance literature:

With potassium phosphate; (±)-trans-1,2-diaminocyclohexane; copper(l) iodide; In 1,4-dioxane; N,N-dimethyl-formamide; at 110 ℃; for 20h;

Reference yield:

2-fluoro-5-iodobenzonitrile (351003-36-6) + (R)-3-chloro-2-[2-chloro-5-(5-oxo-pyrrolidin-3-yl)-phenoxy]-benzonitrile (903578-43-8) → 3-chloro-2-{2-chloro-5-[1-(3-cyano-4-fluoro-phenyl)-5-oxo-pyrrolidin-3-yl]-phenoxy}benzonitrile (903579-13-5)

Guidance literature:

With potassium phosphate; (±)-trans-1,2-diaminocyclohexane; copper(l) iodide; In 1,4-dioxane; N,N-dimethyl-formamide; at 110 ℃; for 20h;

upstream raw materials:

3-chloro-2-fluorobenzonitrile

Downstream raw materials:

(R)-3-chloro-2-(2-chloro-5-(1-(4-cyano-3-nitrophenyl)-5-oxopyrrolidin-3-yl)phenoxy)benzonitrile

3-chloro-2-{2-chloro-5-[1-(3-cyano-4-fluoro-phenyl)-5-oxo-pyrrolidin-3-yl]-phenoxy}benzonitrile