(1R,2R,3R,4R,5S,6S)-1-acetylmethyl-2,3-di-O-benzyl-4-hydroxy-5-methoxy-6-nitrocyclohexane

Base Information

• Chemical Name: (1R,2R,3R,4R,5S,6S)-1-acetylmethyl-2,3-di-O-benzyl-4-hydroxy-5-methoxy-6-nitrocyclohexane
• CAS No.: 1198581-95-1
• Molecular Formula: C₂₄H₂₉NO₇
• Molecular Weight: 443.497
• Mol file: 1198581-95-1.mol

Synonyms:(1R,2R,3R,4R,5S,6S)-1-acetylmethyl-2,3-di-O-benzyl-4-hydroxy-5-methoxy-6-nitrocyclohexane

Chemical Property of (1R,2R,3R,4R,5S,6S)-1-acetylmethyl-2,3-di-O-benzyl-4-hydroxy-5-methoxy-6-nitrocyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R,3R,4R,5S,6S)-1-acetylmethyl-2,3-di-O-benzyl-4-hydroxy-5-methoxy-6-nitrocyclohexane

There total 1 articles about (1R,2R,3R,4R,5S,6S)-1-acetylmethyl-2,3-di-O-benzyl-4-hydroxy-5-methoxy-6-nitrocyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C23H25NO6 (1198582-02-3) → (1R,2R,3R,4R,5S,6S)-1-acetylmethyl-2,3-di-O-benzyl-4-hydroxy-5-methoxy-6-nitrocyclohexane (1198581-95-1) + (1S,2R,3R,4R,5R,6S)-1-acetylmethyl-2,3-di-O-benzyl-4-hydroxy-5-methoxy-6-nitrocyclohexane (1198581-96-2)

Guidance literature:

With sodium methylate; In methanol; at 20 ℃; for 2h;

DOI:10.1016/j.carres.2009.08.028

Reference yield: 54.0%

(1R,2R,3R,4R,5S,6S)-1-acetylmethyl-2,3-di-O-benzyl-4-hydroxy-5-methoxy-6-nitrocyclohexane (1198581-95-1) + benzylamine (100-46-9) → (1R,3R,5S,6R,7R,8S,9R)-2-benzyl-6,7-di-O-benzyl-3-methyl-9-nitro-3,8-oxy-2-azabicyclo[3.3.1]nonane (1198581-94-0) + (1S,5R,6R,7R,8R,9S)-2-benzyl-6,7-di-O-benzyl-8-hydroxy-3-methyl-9-nitro-2-azabicyclo[3.3.1]nonan-3-ene

Guidance literature:

(1R,2R,3R,4R,5S,6S)-1-acetylmethyl-2,3-di-O-benzyl-4-hydroxy-5-methoxy-6-nitrocyclohexane; With sodium methylate; In methanol; at 20 ℃; for 2h;

benzylamine; In methanol; at 20 ℃;

DOI:10.1016/j.carres.2009.08.028

Reference yield:

(1R,2R,3R,4R,5S,6S)-1-acetylmethyl-2,3-di-O-benzyl-4-hydroxy-5-methoxy-6-nitrocyclohexane (1198581-95-1) + 1-amino-2-propene (107-11-9,30551-89-4) → (1S,5R,6R,7R,8R,9S)-2-allyl-6,7-di-O-benzyl-8-hydroxy-3-methyl-9-nitro-2-azabicyclo[3.3.1]nonan-3-ene

Guidance literature:

With sodium methylate; In methanol; at 20 ℃; for 2h;

DOI:10.1016/j.carres.2009.08.028

upstream raw materials:

C₂₃H₂₅NO₆

Downstream raw materials:

(1R,3R,5S,6R,7R,8S,9R)-2-benzyl-6,7-di-O-benzyl-3-methyl-9-nitro-3,8-oxy-2-azabicyclo[3.3.1]nonane