C₁₄H₁₈ClN

Base Information

• Chemical Name: C₁₄H₁₈ClN
• CAS No.: 1428988-95-7
• Molecular Formula: C₁₄H₁₈ClN
• Molecular Weight: 235.757
• Mol file: 1428988-95-7.mol

Synonyms:C₁₄H₁₈ClN

Chemical Property of C₁₄H₁₈ClN

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of C₁₄H₁₈ClN

There total 1 articles about C₁₄H₁₈ClN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C14H19N (1428989-05-2) → C14H18ClN (1428988-95-7)

Guidance literature:

With N-chloro-succinimide; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/ol4003866

Reference yield:

C14H18ClN (1428988-95-7) → C14H18IN

Guidance literature:

With sodium iodide; In tert-butyl alcohol; at 70 ℃; regioselective reaction;

DOI:10.1021/ol4003866

Reference yield:

C14H18ClN (1428988-95-7) → 5-benzyl-7-fluoro-5-azaspiro[2.5]octane (1428989-16-5) + 5-benzyl-6-(fluoromethyl)-5-azaspiro[2.4]heptane (1428989-17-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium iodide / tert-butyl alcohol / 70 °C

2: silver fluoride / tert-butyl alcohol / 70 °C

With silver fluoride; sodium iodide; In tert-butyl alcohol;

DOI:10.1021/ol4003866

upstream raw materials:

C₁₄H₁₉N

Downstream raw materials:

5-benzyl-7-fluoro-5-azaspiro[2.5]octane

5-benzyl-6-(fluoromethyl)-5-azaspiro[2.4]heptane

7-azido-5-benzyl-5-azaspiro[2.5]octane

6-(azidomethyl)-5-benzyl-5-azaspiro[2.4]heptane