2-(2-Formyl-5-methoxyphenyl)-6,6-dimethyl-8-phenylsulfonyloct-7-enoic acid

Base Information

Chemical Name:2-(2-Formyl-5-methoxyphenyl)-6,6-dimethyl-8-phenylsulfonyloct-7-enoic acid
CAS No.:161141-57-7
Molecular Formula:C₂₄H₂₈O₆S
Molecular Weight:444.549
Hs Code.:

Synonyms:2-(2-Formyl-5-methoxyphenyl)-6,6-dimethyl-8-phenylsulfonyloct-7-enoic acid

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Chemical Property of 2-(2-Formyl-5-methoxyphenyl)-6,6-dimethyl-8-phenylsulfonyloct-7-enoic acid

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Technology Process of 2-(2-Formyl-5-methoxyphenyl)-6,6-dimethyl-8-phenylsulfonyloct-7-enoic acid

There total 9 articles about 2-(2-Formyl-5-methoxyphenyl)-6,6-dimethyl-8-phenylsulfonyloct-7-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 193215-67-7
(E)-8-Benzenesulfonyl-2-(2-formyl-5-methoxy-phenyl)-6,6-dimethyl-oct-7-enoic acid methyl ester

: 161141-57-7
2-(2-Formyl-5-methoxyphenyl)-6,6-dimethyl-8-phenylsulfonyloct-7-enoic acid

Guidance literature:: With potassium carbonate; In methanol; Ambient temperature;
DOI:10.1039/a701589e

Reference yield:

: 161141-55-5
4-(4,4-Dimethyl-6-phenylsulfonylhex-5-enyl)-6-methoxychroman-3-one

: 161141-57-7
2-(2-Formyl-5-methoxyphenyl)-6,6-dimethyl-8-phenylsulfonyloct-7-enoic acid

Guidance literature:: Multistep reaction;
DOI:10.1039/c39940002145

Reference yield:

: 161141-47-5
6-Methoxy-4-(4,4-dimethylhex-5-enyl)isochroman-3-one

: 161141-57-7
2-(2-Formyl-5-methoxyphenyl)-6,6-dimethyl-8-phenylsulfonyloct-7-enoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) O₃, 2.) dimethyl sulfide / 1.) CH₂Cl₂, MeOH, -78 deg C, 0.5 h, 2.) r.t., 3 h

2: n-BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 10 min, 2.) -78 deg C, 2.5 h; -78 deg C to r.t., 1 h

3: Et₃N, methanesulfonyl chloride / CH₂Cl₂ / 1 h

4: aq. K₂CO₃ / methanol / 3.5 h / Ambient temperature

5: diethyl ether

6: 1.) DMSO, oxalyl chloride, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 0.5 h, 2.) -78 deg C to r.t.

7: 92 percent / aq. K₂CO₃ / methanol / Ambient temperature

With n-butyllithium; oxalyl dichloride; dimethylsulfide; potassium carbonate; ozone; dimethyl sulfoxide; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane;
DOI:10.1039/a701589e