(3S,4S)-1-Benzenesulfonyl-1-[(1R,3R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-cyclohexyl]-4-[1,3]dithian-2-yl-3-(4-methoxy-benzyloxy)-pentan-2-one

Base Information

Chemical Name:(3S,4S)-1-Benzenesulfonyl-1-[(1R,3R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-cyclohexyl]-4-[1,3]dithian-2-yl-3-(4-methoxy-benzyloxy)-pentan-2-one
CAS No.:128694-61-1
Molecular Formula:C₄₆H₅₈O₇S₃Si
Molecular Weight:847.246
Hs Code.:

(3S,4S)-1-Benzenesulfonyl-1-[(1R,3R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-cyclohexyl]-4-[1,3]dithian-2-yl-3-(4-methoxy-benzyloxy)-pentan-2-one

Synonyms:(3S,4S)-1-Benzenesulfonyl-1-[(1R,3R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-cyclohexyl]-4-[1,3]dithian-2-yl-3-(4-methoxy-benzyloxy)-pentan-2-one

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Chemical Property of (3S,4S)-1-Benzenesulfonyl-1-[(1R,3R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-cyclohexyl]-4-[1,3]dithian-2-yl-3-(4-methoxy-benzyloxy)-pentan-2-one

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Technology Process of (3S,4S)-1-Benzenesulfonyl-1-[(1R,3R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-cyclohexyl]-4-[1,3]dithian-2-yl-3-(4-methoxy-benzyloxy)-pentan-2-one

There total 15 articles about (3S,4S)-1-Benzenesulfonyl-1-[(1R,3R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-cyclohexyl]-4-[1,3]dithian-2-yl-3-(4-methoxy-benzyloxy)-pentan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 128694-60-0
(3S,4S)-1-Benzenesulfonyl-1-[(1R,3R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-cyclohexyl]-4-[1,3]dithian-2-yl-3-(4-methoxy-benzyloxy)-pentan-2-ol

: 128694-61-1
(3S,4S)-1-Benzenesulfonyl-1-[(1R,3R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-cyclohexyl]-4-[1,3]dithian-2-yl-3-(4-methoxy-benzyloxy)-pentan-2-one

Guidance literature:: With dimethyl sulfoxide; trifluoroacetic anhydride; In dichloromethane; at -78 ℃;
DOI:10.1016/S0040-4039(01)93398-2

Reference yield:

: 5709-98-8
(R)-cyclohex-3-enecarboxylic acid

: 128694-61-1
(3S,4S)-1-Benzenesulfonyl-1-[(1R,3R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-cyclohexyl]-4-[1,3]dithian-2-yl-3-(4-methoxy-benzyloxy)-pentan-2-one

Guidance literature:: Multi-step reaction with 10 steps

1: 93 percent / I₂/KI, NaHCO₃ / H₂O / 0 °C

2: 96 percent / DBU / tetrahydrofuran / Heating

3: 93 percent / LiAlH₄ / diethyl ether / 0 °C

4: 70 percent / n-Bu₃P / dimethylformamide / Ambient temperature

5: 94 percent / BF₃*Et₂O / diethyl ether / 0 °C

6: 87 percent / oxone / tetrahydrofuran; methanol; H₂O / 0 °C

7: 71 percent / BH₃*THF, NaOH, t-BuO₂H / -78 deg C to room temp.

8: 70 percent / imidazole / dimethylformamide / Ambient temperature

9: 89 percent / n-BuLi / tetrahydrofuran / -78 °C

10: 84 percent / TFAA, DMSO / CH₂Cl₂ / -78 °C

With 1H-imidazole; tert.-butylhydroperoxide; Oxone; sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; borane-THF; tributylphosphine; boron trifluoride diethyl etherate; iodine; sodium hydrogencarbonate; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic anhydride; potassium iodide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)93398-2

Reference yield:

: 2186-92-7
p-Anisaldehyde dimethyl acetal

: 128694-61-1
(3S,4S)-1-Benzenesulfonyl-1-[(1R,3R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-3-methoxy-cyclohexyl]-4-[1,3]dithian-2-yl-3-(4-methoxy-benzyloxy)-pentan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: TsOH / dimethylformamide / 55 °C

2: 90 percent / DIBAL-H / CH₂Cl₂ / -78 °C

3: SO₃*pyridine, DMSO, Et₃N / CH₂Cl₂ / 0 °C

4: 89 percent / n-BuLi / tetrahydrofuran / -78 °C

5: 84 percent / TFAA, DMSO / CH₂Cl₂ / -78 °C

With n-butyllithium; pyridine-SO₃ complex; diisobutylaluminium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)93398-2