5-[2-(8-biotinamido-3,6-dioxaoctyl)-4-(3-trifluoromethyl-3H-diazirin-3-yl)benzamido]pentylamine

Base Information

• Chemical Name: 5-[2-(8-biotinamido-3,6-dioxaoctyl)-4-(3-trifluoromethyl-3H-diazirin-3-yl)benzamido]pentylamine
• CAS No.: 328273-45-6
• Molecular Formula: C₃₀H₄₄F₃N₇O₆S
• Molecular Weight: 687.784
• Mol file: 328273-45-6.mol

Synonyms:5-[2-(8-biotinamido-3,6-dioxaoctyl)-4-(3-trifluoromethyl-3H-diazirin-3-yl)benzamido]pentylamine

Chemical Property of 5-[2-(8-biotinamido-3,6-dioxaoctyl)-4-(3-trifluoromethyl-3H-diazirin-3-yl)benzamido]pentylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[2-(8-biotinamido-3,6-dioxaoctyl)-4-(3-trifluoromethyl-3H-diazirin-3-yl)benzamido]pentylamine

There total 3 articles about 5-[2-(8-biotinamido-3,6-dioxaoctyl)-4-(3-trifluoromethyl-3H-diazirin-3-yl)benzamido]pentylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

{5-[2-[2-(2-{2-[5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-ethoxy}-ethoxy)-ethoxy]-4-(3-trifluoromethyl-3H-diazirin-3-yl)-benzoylamino]-pentyl}-carbamic acid tert-butyl ester → 5-[2-(8-biotinamido-3,6-dioxaoctyl)-4-(3-trifluoromethyl-3H-diazirin-3-yl)benzamido]pentylamine (328273-45-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 0.5h;

DOI:10.1016/S0040-4020(00)00752-3

Reference yield:

5-tert-butoxycarbonylamino-1-aminopentane (51644-96-3) → 5-[2-(8-biotinamido-3,6-dioxaoctyl)-4-(3-trifluoromethyl-3H-diazirin-3-yl)benzamido]pentylamine (328273-45-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / HOBt; EDC; Et₃N / dimethylformamide / 72 h / 0 °C

2: 71 percent / trifluoroacetic acid / CH₂Cl₂ / 0.5 h / 0 - 20 °C

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; 1: Substitution / 2: Hydrolysis;

DOI:10.1016/S0040-4020(00)00752-3

Reference yield:

Hatanaka reagent → 5-[2-(8-biotinamido-3,6-dioxaoctyl)-4-(3-trifluoromethyl-3H-diazirin-3-yl)benzamido]pentylamine (328273-45-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / HOBt; EDC; Et₃N / dimethylformamide / 72 h / 0 °C

2: 71 percent / trifluoroacetic acid / CH₂Cl₂ / 0.5 h / 0 - 20 °C

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; 1: Substitution / 2: Hydrolysis;

DOI:10.1016/S0040-4020(00)00752-3

upstream raw materials:

5-tert-butoxycarbonylamino-1-aminopentane