1-Naphthalenol,2-ethyl-6,7-difluoro-1,2-dihydro-,(1R,2R)-(9CI)

Base Information

• Chemical Name: 1-Naphthalenol,2-ethyl-6,7-difluoro-1,2-dihydro-,(1R,2R)-(9CI)
• CAS No.: 769154-38-3
• Molecular Formula: C₁₂H₁₂F₂O
• Molecular Weight: 210.223
• Mol file: 769154-38-3.mol

Synonyms:1-Naphthalenol,2-ethyl-6,7-difluoro-1,2-dihydro-,(1R,2R)-(9CI)

Chemical Property of 1-Naphthalenol,2-ethyl-6,7-difluoro-1,2-dihydro-,(1R,2R)-(9CI)

Chemical Property:

• PSA: 20.23000
• LogP: 3.05120

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Naphthalenol,2-ethyl-6,7-difluoro-1,2-dihydro-,(1R,2R)-(9CI)

There total 8 articles about 1-Naphthalenol,2-ethyl-6,7-difluoro-1,2-dihydro-,(1R,2R)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

6,7-difluoro-1,4-dihydro-1,4-epoxynaphthalene (173276-99-8) + diethylzinc (557-20-0) → (1S*,2S*)-2-ethyl-6,7-difluoro-1,2-dihydronaphthalen-1-ol (769154-38-3)

Guidance literature:

With Ni(1,2-bis(diphenylphosphino)ethane)Cl₂; In hexane; toluene; at -40 ℃; for 7h; Inert atmosphere;

DOI:10.1039/c8ob02864h

Reference yield: 79.0%

diethylzinc (557-20-0) + 6,7-difluoro-1,4-epoxy-1,4-dihydronaphthalene (173276-99-8) → (1R,2R)-6,7-difluoro-2-ethyl-1,2-dihydronaphthalen-1-ol (769154-38-3)

Guidance literature:

With sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; (Rp,Rs)-[1-(tBu-sulfenyl)-2-(Cy₂-phosphino)Fc](Cl)(Me)Pd(II); In hexane; toluene; at 20 ℃;

DOI:10.1002/anie.200460087

Reference yield:

diethylzinc (557-20-0) + 6,7-difluoro-1,4-epoxy-1,4-dihydronaphthalene (173276-99-8) → (1R,2R)-6,7-difluoro-2-ethyl-1,2-dihydronaphthalen-1-ol (769154-38-3) + (1S,2S)-2-Ethyl-6,7-difluoro-1,2-dihydro-naphthalen-1-ol

Guidance literature:

With dichloro bis(acetonitrile) palladium(II); (R)-2,2'-bis[bis(3-methylphenyl)phosphino]-1,1'-binaphthyl; In dichloromethane; at 20 ℃; Title compound not separated from byproducts.;

DOI:10.1021/ja993427i

upstream raw materials:

diethylzinc

6,7-difluoro-1,4-epoxy-1,4-dihydronaphthalene

6,7-difluoro-1,4-dihydro-1,4-epoxynaphthalene

ethylmagnesium bromide