(R_SR,R)-(-)-methyl 3-oxo-5-(6-benzyloxyhexyl)-5-(p-toluenesulfinylamino)pentanoate

Base Information

• Chemical Name: (R_SR,R)-(-)-methyl 3-oxo-5-(6-benzyloxyhexyl)-5-(p-toluenesulfinylamino)pentanoate
• CAS No.: 857894-33-8
• Molecular Formula: C₂₆H₃₅NO₅S
• Molecular Weight: 473.634

Synonyms:(R_SR,R)-(-)-methyl 3-oxo-5-(6-benzyloxyhexyl)-5-(p-toluenesulfinylamino)pentanoate

Chemical Property of (R_SR,R)-(-)-methyl 3-oxo-5-(6-benzyloxyhexyl)-5-(p-toluenesulfinylamino)pentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R_SR,R)-(-)-methyl 3-oxo-5-(6-benzyloxyhexyl)-5-(p-toluenesulfinylamino)pentanoate

There total 5 articles about (R_SR,R)-(-)-methyl 3-oxo-5-(6-benzyloxyhexyl)-5-(p-toluenesulfinylamino)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(RSR,R)-(-)-methyl 3-(6-benzyloxyhexyl)-3-(p-toluenesulfinylamino)propanoate (857894-32-7) + acetic acid methyl ester (79-20-9) → (RSR,R)-(-)-methyl 3-oxo-5-(6-benzyloxyhexyl)-5-(p-toluenesulfinylamino)pentanoate (857894-33-8)

Guidance literature:

acetic acid methyl ester; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

(R_SR,R)-(-)-methyl 3-(6-benzyloxyhexyl)-3-(p-toluenesulfinylamino)propanoate; In tetrahydrofuran; diethyl ether; at -78 ℃; for 1h;

DOI:10.1021/jo050373o

Reference yield:

(R)-(-)-7-benzyloxyheptylidene-p-toluenesulfonimide (857894-31-6) → (RSR,R)-(-)-methyl 3-oxo-5-(6-benzyloxyhexyl)-5-(p-toluenesulfinylamino)pentanoate (857894-33-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaHMDS / tetrahydrofuran / 1 h / -78 °C

1.2: 83 percent / tetrahydrofuran; diethyl ether / 1 h / -78 °C

2.1: NaHMDS / tetrahydrofuran / 1 h / -78 °C

2.2: 73 percent / tetrahydrofuran; diethyl ether / 1 h / -78 °C

With sodium hexamethyldisilazane; In tetrahydrofuran;

DOI:10.1021/jo050373o

Reference yield:

7-benzyloxyheptan-1-ol (129649-05-4) → (RSR,R)-(-)-methyl 3-oxo-5-(6-benzyloxyhexyl)-5-(p-toluenesulfinylamino)pentanoate (857894-33-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 78 percent / Ti(OEt)4 / CH₂Cl₂ / 3 h / 20 °C

2.1: NaHMDS / tetrahydrofuran / 1 h / -78 °C

2.2: 83 percent / tetrahydrofuran; diethyl ether / 1 h / -78 °C

3.1: NaHMDS / tetrahydrofuran / 1 h / -78 °C

3.2: 73 percent / tetrahydrofuran; diethyl ether / 1 h / -78 °C

With titanium(IV) tetraethanolate; sodium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo050373o

upstream raw materials:

(R_SR,R)-(-)-methyl 3-(6-benzyloxyhexyl)-3-(p-toluenesulfinylamino)propanoate

acetic acid methyl ester

(R)-(-)-7-benzyloxyheptylidene-p-toluenesulfonimide

7-benzyloxyheptan-1-ol

Downstream raw materials:

(R)-(+)-6-(6-benzyloxyhexyl)-4-(tert-butyldimethylsilanyloxy)-5,6-dihydro-2H-pyridine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester

(6R)-(+)-6-(6-benzyloxyhexyl)-4-hydroxy-5,6-dihydro-2H-pyridine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester

(R)-(-)-6-(6-benzyloxyhexyl)-4-oxo-5,6-dihydro-4H-pyridine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 857894-33-8 (R_SR,R)-(-)-methyl 3-oxo-5-(6-benzyloxyhexyl)-5-(p-toluenesulfinylamino)pentanoate

Send

Send

Metric Ton KG G Pound L ML

Send

Send