(S)-1-[(S)-1-(4-Iodo-phenyl)-ethyl]-2-methyl-4-piperidin-4-yl-piperazine

Base Information

Chemical Name:(S)-1-[(S)-1-(4-Iodo-phenyl)-ethyl]-2-methyl-4-piperidin-4-yl-piperazine
CAS No.:726188-52-9
Molecular Formula:C₁₈H₂₈IN₃
Molecular Weight:413.345
Hs Code.:

Synonyms:(S)-1-[(S)-1-(4-Iodo-phenyl)-ethyl]-2-methyl-4-piperidin-4-yl-piperazine

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Chemical Property of (S)-1-[(S)-1-(4-Iodo-phenyl)-ethyl]-2-methyl-4-piperidin-4-yl-piperazine

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Technology Process of (S)-1-[(S)-1-(4-Iodo-phenyl)-ethyl]-2-methyl-4-piperidin-4-yl-piperazine

There total 8 articles about (S)-1-[(S)-1-(4-Iodo-phenyl)-ethyl]-2-methyl-4-piperidin-4-yl-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 306297-60-9
4-{4-[1-(S)-(4-iodophenyl)ethyl]-3(S)-methyl-1-piperazinyl}-1-(tert-butoxycarbonyl)piperidine

: 726188-52-9
(S)-1-[(S)-1-(4-Iodo-phenyl)-ethyl]-2-methyl-4-piperidin-4-yl-piperazine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jm0155401

Reference yield:

: 2627-86-3
(S)-1-phenyl-ethylamine

: 726188-52-9
(S)-1-[(S)-1-(4-Iodo-phenyl)-ethyl]-2-methyl-4-piperidin-4-yl-piperazine

Guidance literature:: Multi-step reaction with 8 steps

1.1: CH₂Cl₂ / 1.25 h / 20 °C / cooling

2.1: 36.5 g / I₂; PhI(OCOCF₃)2 / 20 °C / cooling

3.1: NaOH / methanol; H₂O / 2.5 h / 20 °C

4.1: 8.27 g / K₂CO₃ / H₂O / 20 °C

5.1: CH₂Cl₂ / 3 h / Heating

5.2: 14.3 g / methyl sulfoxide; NaI; aq. NH₃ / 0 - 20 °C

6.1: 98 percent / NaBH₄; BF₃*OEt₂ / 1,2-dimethoxy-ethane / 3 h / Heating

7.1: 2.21 g / NaB(OAc)3H; 2M AcOH / CH₂Cl₂

8.1: 85 percent / trifluoroacetyc acid / CH₂Cl₂ / 2 h / 20 °C

With sodium hydroxide; sodium tetrahydroborate; boron trifluoride diethyl etherate; iodine; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; trifluoroacetic acid; bis-[(trifluoroacetoxy)iodo]benzene; In methanol; 1,2-dimethoxyethane; dichloromethane; water; 5.1: chloroacetylation / 5.2: cyclization;
DOI:10.1021/jm0155401

Reference yield:

: 2354-91-8,28332-81-2,39995-50-1,39995-51-2
(S)-2,2,2-trifluoro-(α-methylbenzyl)acetamide

: 726188-52-9
(S)-1-[(S)-1-(4-Iodo-phenyl)-ethyl]-2-methyl-4-piperidin-4-yl-piperazine

Guidance literature:: Multi-step reaction with 7 steps

1.1: 36.5 g / I₂; PhI(OCOCF₃)2 / 20 °C / cooling

2.1: NaOH / methanol; H₂O / 2.5 h / 20 °C

3.1: 8.27 g / K₂CO₃ / H₂O / 20 °C

4.1: CH₂Cl₂ / 3 h / Heating

4.2: 14.3 g / methyl sulfoxide; NaI; aq. NH₃ / 0 - 20 °C

5.1: 98 percent / NaBH₄; BF₃*OEt₂ / 1,2-dimethoxy-ethane / 3 h / Heating

6.1: 2.21 g / NaB(OAc)3H; 2M AcOH / CH₂Cl₂

7.1: 85 percent / trifluoroacetyc acid / CH₂Cl₂ / 2 h / 20 °C

With sodium hydroxide; sodium tetrahydroborate; boron trifluoride diethyl etherate; iodine; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; trifluoroacetic acid; bis-[(trifluoroacetoxy)iodo]benzene; In methanol; 1,2-dimethoxyethane; dichloromethane; water; 4.1: chloroacetylation / 4.2: cyclization;
DOI:10.1021/jm0155401