2-(4-chlorophenyl)-2-(6-fluoro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-isobutylacetamide

Base Information

Chemical Name:2-(4-chlorophenyl)-2-(6-fluoro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-isobutylacetamide
CAS No.:1444176-36-6
Molecular Formula:C₁₉H₁₉ClFN₃O₂
Molecular Weight:375.83
Hs Code.:

Synonyms:2-(4-chlorophenyl)-2-(6-fluoro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-isobutylacetamide

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Chemical Property of 2-(4-chlorophenyl)-2-(6-fluoro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-isobutylacetamide

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Technology Process of 2-(4-chlorophenyl)-2-(6-fluoro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-isobutylacetamide

There total 2 articles about 2-(4-chlorophenyl)-2-(6-fluoro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-isobutylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1444176-34-4
methyl 2-(1-(4-chlorophenyl)-2-(isobutylamino)-2-oxoethylamino)-4-fluorophenylcarbamate

: 1444176-36-6
2-(4-chlorophenyl)-2-(6-fluoro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-isobutylacetamide

Guidance literature:: With potassium carbonate; at 130 ℃; for 0.5h; Microwave irradiation;
DOI:10.1016/j.bmc.2012.06.020

Reference yield:

: 1019389-20-8
C₈H₉FN₂O₂

: 590-94-3
2-methylpropylisonitrile

: 104-88-1
4-chlorobenzaldehyde

: 1444176-36-6
2-(4-chlorophenyl)-2-(6-fluoro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-isobutylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: phenylphosphinic acid / tetrahydrofuran / 24 h / 20 °C

2: potassium carbonate / 0.5 h / 130 °C / Microwave irradiation

With phenylphosphinic acid; potassium carbonate; In tetrahydrofuran; 1: |Ugi Condensation;
DOI:10.1016/j.bmc.2012.06.020