(2'S,4'R,6'S)-2'-(2'-pyridin-3''-yl-ethyl)-6'-(4''''-allyloxyphenyl)tetrahydropyran-4'-yl acetate

Base Information

Chemical Name:(2'S,4'R,6'S)-2'-(2'-pyridin-3''-yl-ethyl)-6'-(4''''-allyloxyphenyl)tetrahydropyran-4'-yl acetate
CAS No.:1440432-56-3
Molecular Formula:C₂₃H₂₇NO₄
Molecular Weight:381.472
Hs Code.:

Synonyms:(2'S,4'R,6'S)-2'-(2'-pyridin-3''-yl-ethyl)-6'-(4''''-allyloxyphenyl)tetrahydropyran-4'-yl acetate

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Chemical Property of (2'S,4'R,6'S)-2'-(2'-pyridin-3''-yl-ethyl)-6'-(4''''-allyloxyphenyl)tetrahydropyran-4'-yl acetate

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Technology Process of (2'S,4'R,6'S)-2'-(2'-pyridin-3''-yl-ethyl)-6'-(4''''-allyloxyphenyl)tetrahydropyran-4'-yl acetate

There total 2 articles about (2'S,4'R,6'S)-2'-(2'-pyridin-3''-yl-ethyl)-6'-(4''''-allyloxyphenyl)tetrahydropyran-4'-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 2754-27-0
trimethylsilyl acetate

: 40663-68-1
4-(2-propenyloxy)benzaldehyde

: 1440432-77-8
(S)-1-(pyridin-3'-yl)hex-5-ene-3-ol

: 1440432-56-3
(2'S,4'R,6'S)-2'-(2'-pyridin-3''-yl-ethyl)-6'-(4''''-allyloxyphenyl)tetrahydropyran-4'-yl acetate

Guidance literature:: trimethylsilyl acetate; 4-(2-propenyloxy)benzaldehyde; (S)-1-(pyridin-3'-yl)hex-5-ene-3-ol; With acetic acid; In dichloromethane; at 20 ℃; for 0.166667h; Inert atmosphere;

With boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1002/anie.201205728

Reference yield:

: 1802-16-0
3-(3-pyridinyl)propionaldehyde

: 1440432-56-3
(2'S,4'R,6'S)-2'-(2'-pyridin-3''-yl-ethyl)-6'-(4''''-allyloxyphenyl)tetrahydropyran-4'-yl acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: B-chlorodiisopinocampheylborane / tetrahydrofuran / 2.5 h / -75 - 20 °C

1.2: 2.5 h / -100 - 20 °C

2.1: acetic acid / dichloromethane / 0.17 h / 20 °C / Inert atmosphere

2.2: 18 h / 20 °C / Inert atmosphere

With acetic acid; B-chlorodiisopinocampheylborane; In tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.201205728