(3S,4aR,8aS)-3-(tert-Butyl-diphenyl-silanyloxy)-8-[4-(tert-butyl-diphenyl-silanyloxymethyl)-2,6-bis-methoxymethoxy-benzyl]-4,4,7,8a-tetramethyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalene

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Chemical Name:(3S,4aR,8aS)-3-(tert-Butyl-diphenyl-silanyloxy)-8-[4-(tert-butyl-diphenyl-silanyloxymethyl)-2,6-bis-methoxymethoxy-benzyl]-4,4,7,8a-tetramethyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalene
CAS No.:193471-32-8
Molecular Formula:C₅₈H₇₆O₆Si₂
Molecular Weight:925.409
Hs Code.:

(3S,4aR,8aS)-3-(tert-Butyl-diphenyl-silanyloxy)-8-[4-(tert-butyl-diphenyl-silanyloxymethyl)-2,6-bis-methoxymethoxy-benzyl]-4,4,7,8a-tetramethyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalene

Synonyms:(3S,4aR,8aS)-3-(tert-Butyl-diphenyl-silanyloxy)-8-[4-(tert-butyl-diphenyl-silanyloxymethyl)-2,6-bis-methoxymethoxy-benzyl]-4,4,7,8a-tetramethyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalene

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Chemical Property of (3S,4aR,8aS)-3-(tert-Butyl-diphenyl-silanyloxy)-8-[4-(tert-butyl-diphenyl-silanyloxymethyl)-2,6-bis-methoxymethoxy-benzyl]-4,4,7,8a-tetramethyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalene

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Technology Process of (3S,4aR,8aS)-3-(tert-Butyl-diphenyl-silanyloxy)-8-[4-(tert-butyl-diphenyl-silanyloxymethyl)-2,6-bis-methoxymethoxy-benzyl]-4,4,7,8a-tetramethyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalene

There total 10 articles about (3S,4aR,8aS)-3-(tert-Butyl-diphenyl-silanyloxy)-8-[4-(tert-butyl-diphenyl-silanyloxymethyl)-2,6-bis-methoxymethoxy-benzyl]-4,4,7,8a-tetramethyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: {4-[(4aR,6S,8aS)-6-(tert-Butyl-diphenyl-silanyloxy)-2,5,5,8a-tetramethyl-3,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-ylmethyl]-3,5-bis-methoxymethoxy-phenyl}-methanol

: 193471-32-8
(3S,4aR,8aS)-3-(tert-Butyl-diphenyl-silanyloxy)-8-[4-(tert-butyl-diphenyl-silanyloxymethyl)-2,6-bis-methoxymethoxy-benzyl]-4,4,7,8a-tetramethyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalene

Guidance literature:: With dmap; In pyridine; at 23 ℃; for 4h; Yield given;
DOI:10.1016/S0040-4039(97)01146-5

Reference yield:

: 157519-07-8
(4aS,6S,8aS)-6-(tert-Butyl-diphenyl-silanyloxy)-2,5,5,8a-tetramethyl-4a,5,6,7,8,8a-hexahydro-4H-naphthalen-1-one

: 193471-32-8
(3S,4aR,8aS)-3-(tert-Butyl-diphenyl-silanyloxy)-8-[4-(tert-butyl-diphenyl-silanyloxymethyl)-2,6-bis-methoxymethoxy-benzyl]-4,4,7,8a-tetramethyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalene

Guidance literature:: Multi-step reaction with 9 steps

1: n-BuLi / 10 h / -78 deg C to 23 deg C

2: Me₃SiCl/NaI / acetonitrile / 0.5 h / 0 - 23 °C

3: NaBH₄ / methanol / 1 h / -78 - 0 °C

4: Et₃N / CH₂Cl₂ / 0.25 h / -78 °C

5: LiBr / tetrahydrofuran / 1 h / 0 °C

6: 1.) n-BuLi, TMEDA, 2.) CuCN / 1.) THF, -20 deg C, 40 min, 2.) THF, -20 deg C, 40 min, 3.) THF, -78 deg C, 2 h

7: 1N HCl / tetrahydrofuran / 1 h / 23 °C

8: NaBH₄ / methanol; tetrahydrofuran / 0.25 h / 0 °C

9: DMAP / pyridine / 4 h / 23 °C

With hydrogenchloride; dmap; sodium tetrahydroborate; n-butyllithium; chloro-trimethyl-silane; N,N,N,N,-tetramethylethylenediamine; triethylamine; sodium iodide; lithium bromide; In tetrahydrofuran; pyridine; methanol; dichloromethane; acetonitrile;
DOI:10.1016/S0040-4039(97)01146-5

Reference yield:

: 157519-06-7
(1R,4aS,6S,8aS)-6-(tert-Butyl-diphenyl-silanyloxy)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-ol

: 193471-32-8
(3S,4aR,8aS)-3-(tert-Butyl-diphenyl-silanyloxy)-8-[4-(tert-butyl-diphenyl-silanyloxymethyl)-2,6-bis-methoxymethoxy-benzyl]-4,4,7,8a-tetramethyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalene

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -60 deg C, 2.) CH₂Cl₂, -60 deg C to 23 deg C, 1 h

2: n-BuLi / 10 h / -78 deg C to 23 deg C

3: Me₃SiCl/NaI / acetonitrile / 0.5 h / 0 - 23 °C

4: NaBH₄ / methanol / 1 h / -78 - 0 °C

5: Et₃N / CH₂Cl₂ / 0.25 h / -78 °C

6: LiBr / tetrahydrofuran / 1 h / 0 °C

7: 1.) n-BuLi, TMEDA, 2.) CuCN / 1.) THF, -20 deg C, 40 min, 2.) THF, -20 deg C, 40 min, 3.) THF, -78 deg C, 2 h

8: 1N HCl / tetrahydrofuran / 1 h / 23 °C

9: NaBH₄ / methanol; tetrahydrofuran / 0.25 h / 0 °C

10: DMAP / pyridine / 4 h / 23 °C

With hydrogenchloride; dmap; sodium tetrahydroborate; n-butyllithium; chloro-trimethyl-silane; oxalyl dichloride; N,N,N,N,-tetramethylethylenediamine; dimethyl sulfoxide; triethylamine; sodium iodide; lithium bromide; In tetrahydrofuran; pyridine; methanol; dichloromethane; acetonitrile;
DOI:10.1016/S0040-4039(97)01146-5