(4R)-4-[((R)-2-{3-[methyl-(N-methyl-(R)-pipecolyl-(S)-isoleucyl)-amino]-4-methyl-pentyl}-thiazole-4-carbonyl)-amino]-5-phenyl-pentanoic acid trifluoroacetic acid salt

Base Information

Chemical Name:(4R)-4-[((R)-2-{3-[methyl-(N-methyl-(R)-pipecolyl-(S)-isoleucyl)-amino]-4-methyl-pentyl}-thiazole-4-carbonyl)-amino]-5-phenyl-pentanoic acid trifluoroacetic acid salt
CAS No.:1174764-24-9
Molecular Formula:C₂HF₃O₂*C₃₅H₅₃N₅O₅S
Molecular Weight:769.926
Hs Code.:

(4R)-4-[((R)-2-{3-[methyl-(N-methyl-(R)-pipecolyl-(S)-isoleucyl)-amino]-4-methyl-pentyl}-thiazole-4-carbonyl)-amino]-5-phenyl-pentanoic acid trifluoroacetic acid salt

Synonyms:(4R)-4-[((R)-2-{3-[methyl-(N-methyl-(R)-pipecolyl-(S)-isoleucyl)-amino]-4-methyl-pentyl}-thiazole-4-carbonyl)-amino]-5-phenyl-pentanoic acid trifluoroacetic acid salt

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Chemical Property of (4R)-4-[((R)-2-{3-[methyl-(N-methyl-(R)-pipecolyl-(S)-isoleucyl)-amino]-4-methyl-pentyl}-thiazole-4-carbonyl)-amino]-5-phenyl-pentanoic acid trifluoroacetic acid salt

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Technology Process of (4R)-4-[((R)-2-{3-[methyl-(N-methyl-(R)-pipecolyl-(S)-isoleucyl)-amino]-4-methyl-pentyl}-thiazole-4-carbonyl)-amino]-5-phenyl-pentanoic acid trifluoroacetic acid salt

There total 24 articles about (4R)-4-[((R)-2-{3-[methyl-(N-methyl-(R)-pipecolyl-(S)-isoleucyl)-amino]-4-methyl-pentyl}-thiazole-4-carbonyl)-amino]-5-phenyl-pentanoic acid trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1266174-40-6
C₃₆H₅₅N₅O₅S

: 76-05-1
trifluoroacetic acid

: 1174764-24-9
(4R)-4-[((R)-2-{3-[methyl-(N-methyl-(R)-pipecolyl-(S)-isoleucyl)-amino]-4-methyl-pentyl}-thiazole-4-carbonyl)-amino]-5-phenyl-pentanoic acid trifluoroacetic acid salt

Guidance literature:: C₃₆H₅₅N₅O₅S; With sodium hydroxide; In 1,4-dioxane; at 0 ℃;

trifluoroacetic acid; In water; pH=2;
DOI:10.1002/ejoc.200900999

Reference yield:

: 1053805-75-6
(R)-ethyl 2-(3-((tert-butoxycarbonyl)(methyl)amino)-4-methylpentyl)thiazole-4-carboxylate

: 1174764-24-9
(4R)-4-[((R)-2-{3-[methyl-(N-methyl-(R)-pipecolyl-(S)-isoleucyl)-amino]-4-methyl-pentyl}-thiazole-4-carbonyl)-amino]-5-phenyl-pentanoic acid trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 10 steps

1.1: hydrogenchloride / 1,4-dioxane / 0 °C

2.1: 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / -10 - 20 °C

3.1: hydrogen bromide / acetic acid / 0 °C

4.1: sodium hydrogencarbonate / water

4.2: -20 - 20 °C

5.1: sodium hydroxide / 1,4-dioxane / 0 °C

5.2: pH 2

6.1: 4-methyl-morpholine / tetrahydrofuran / 0.17 h

7.1: 4-methyl-morpholine / tetrahydrofuran / -20 - 20 °C

8.1: hydrogen bromide / acetic acid / 0 °C

9.1: methanol / 3 h / 20 °C

10.1: sodium hydroxide / 1,4-dioxane / 0 °C

10.2: pH 2

With 4-methyl-morpholine; hydrogenchloride; hydrogen bromide; 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetic acid;
DOI:10.1002/ejoc.200900999

Reference yield:

: 1174764-17-0
ethyl (R)-2-{3-[(N-benzyloxycarbonyl-(S)-isoleucyl)methylamino]-4-methylpentyl}thiazole-4-carboxylate

: 1174764-24-9
(4R)-4-[((R)-2-{3-[methyl-(N-methyl-(R)-pipecolyl-(S)-isoleucyl)-amino]-4-methyl-pentyl}-thiazole-4-carbonyl)-amino]-5-phenyl-pentanoic acid trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogen bromide / acetic acid / 0 °C

2.1: sodium hydrogencarbonate / water

2.2: -20 - 20 °C

3.1: sodium hydroxide / 1,4-dioxane / 0 °C

3.2: pH 2

4.1: 4-methyl-morpholine / tetrahydrofuran / 0.17 h

5.1: 4-methyl-morpholine / tetrahydrofuran / -20 - 20 °C

6.1: hydrogen bromide / acetic acid / 0 °C

7.1: methanol / 3 h / 20 °C

8.1: sodium hydroxide / 1,4-dioxane / 0 °C

8.2: pH 2

With 4-methyl-morpholine; hydrogen bromide; sodium hydrogencarbonate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; acetic acid;
DOI:10.1002/ejoc.200900999