1-(sec-butyl)-4-(3-fluoro-4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one

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Chemical Name:1-(sec-butyl)-4-(3-fluoro-4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one
CAS No.:1427177-63-6
Molecular Formula:C₂₂H₂₆FN₅O₂
Molecular Weight:411.479
Hs Code.:

Synonyms:1-(sec-butyl)-4-(3-fluoro-4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one

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Chemical Property of 1-(sec-butyl)-4-(3-fluoro-4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one

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Technology Process of 1-(sec-butyl)-4-(3-fluoro-4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one

There total 7 articles about 1-(sec-butyl)-4-(3-fluoro-4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1427177-62-5
1-(sec-butyl)-4-(3-fluoro-4-(4-(4-methoxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one

: 1427177-63-6
1-(sec-butyl)-4-(3-fluoro-4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one

Guidance literature:: With hydrogen bromide; In water; at 120 ℃;

Reference yield:

: 1427177-61-4
4-(3-fluoro-4-(4-(4-methoxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one

: 1427177-63-6
1-(sec-butyl)-4-(3-fluoro-4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / dimethyl sulfoxide / 80 °C

2: hydrogen bromide / water / 120 °C

With hydrogen bromide; potassium carbonate; In water; dimethyl sulfoxide;

Reference yield:

: 154590-33-7
1-(2-fluoro-4-nitrophenyl)piperazine

: 1427177-63-6
1-(sec-butyl)-4-(3-fluoro-4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / 80 °C / Inert atmosphere

2.1: hydrazine hydrate; palladium 10% on activated carbon / ethanol / 3.5 h / Reflux

3.1: pyridine / 16 h / 20 °C

4.1: hydrazine hydrate / 1,4-dioxane / 3 h / Reflux

4.2: 3 h / Reflux

5.1: potassium carbonate / dimethyl sulfoxide / 6 h / 20 °C

5.2: 80 °C

6.1: hydrogen bromide / water / 16 h / Reflux

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen bromide; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; hydrazine hydrate; sodium t-butanolate; In 1,4-dioxane; ethanol; water; dimethyl sulfoxide; toluene; 1.1: |Buchwald-Hartwig Coupling;
DOI:10.1021/acsmedchemlett.9b00438