1-(4-(bis(trimethylsilyl)methyl)-2-(trifluoromethyl)phenyl)-N,N-dimethylmethanamine

Base Information

Chemical Name:1-(4-(bis(trimethylsilyl)methyl)-2-(trifluoromethyl)phenyl)-N,N-dimethylmethanamine
CAS No.:1644191-42-3
Molecular Formula:C₁₇H₃₀F₃NSi₂
Molecular Weight:361.598
Hs Code.:

Synonyms:1-(4-(bis(trimethylsilyl)methyl)-2-(trifluoromethyl)phenyl)-N,N-dimethylmethanamine

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Chemical Property of 1-(4-(bis(trimethylsilyl)methyl)-2-(trifluoromethyl)phenyl)-N,N-dimethylmethanamine

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Technology Process of 1-(4-(bis(trimethylsilyl)methyl)-2-(trifluoromethyl)phenyl)-N,N-dimethylmethanamine

There total 3 articles about 1-(4-(bis(trimethylsilyl)methyl)-2-(trifluoromethyl)phenyl)-N,N-dimethylmethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1644191-23-0
((3-(trifluoromethyl)phenyl)methylene)bis(trimethylsilane)

: 25468-31-9
N-methyl-N-methylenemethanaminium 2,2,2-trifluoroacetate

: 1644191-42-3
1-(4-(bis(trimethylsilyl)methyl)-2-(trifluoromethyl)phenyl)-N,N-dimethylmethanamine

Guidance literature:: ((3-(trifluoromethyl)phenyl)methylene)bis(trimethylsilane); With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; hexane; at -30 ℃; for 1h; Schlenk technique; Inert atmosphere;

With magnesium chloride; In tetrahydrofuran; hexane; at -30 ℃; for 0.25h; Schlenk technique; Inert atmosphere;

N-methyl-N-methylenemethanaminium 2,2,2-trifluoroacetate; Further stages;
DOI:10.1002/chem.201402531

Reference yield:

: 401-78-5
3-bromo-1-trifluoromethylbenzene

: 1644191-42-3
1-(4-(bis(trimethylsilyl)methyl)-2-(trifluoromethyl)phenyl)-N,N-dimethylmethanamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium chloride; magnesium; chloro-trimethyl-silane / tetrahydrofuran; ethylene dibromide / 0.5 h / 0 °C / Schlenk technique; Inert atmosphere

1.2: 2 h / 50 °C / Schlenk technique; Inert atmosphere

2.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / tetrahydrofuran; hexane / 1 h / -30 °C / Schlenk technique; Inert atmosphere

2.2: 0.25 h / -30 °C / Schlenk technique; Inert atmosphere

With chloro-trimethyl-silane; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; magnesium; lithium chloride; In tetrahydrofuran; hexane; ethylene dibromide; 1.2: |Kumada Cross-Coupling;
DOI:10.1002/chem.201402531

Reference yield:

: 29955-12-2
bis(trimethylsilyl)methyl bromide

: 1644191-42-3
1-(4-(bis(trimethylsilyl)methyl)-2-(trifluoromethyl)phenyl)-N,N-dimethylmethanamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium chloride; magnesium; chloro-trimethyl-silane / tetrahydrofuran; ethylene dibromide / 0.5 h / 0 °C / Schlenk technique; Inert atmosphere

1.2: 2 h / 50 °C / Schlenk technique; Inert atmosphere

2.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / tetrahydrofuran; hexane / 1 h / -30 °C / Schlenk technique; Inert atmosphere

2.2: 0.25 h / -30 °C / Schlenk technique; Inert atmosphere

With chloro-trimethyl-silane; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; magnesium; lithium chloride; In tetrahydrofuran; hexane; ethylene dibromide; 1.2: |Kumada Cross-Coupling;
DOI:10.1002/chem.201402531