[2-¹³C]-(3S,4R)-5-(benzyloxy)-3,4-dihydroxypentan-2-one

Base Information

Chemical Name:[2-¹³C]-(3S,4R)-5-(benzyloxy)-3,4-dihydroxypentan-2-one
CAS No.:1589494-00-7
Molecular Formula:C₁₂H₁₆O₄
Molecular Weight:225.246
Hs Code.:

[2-<sup>13</sup>C]-(3S,4R)-5-(benzyloxy)-3,4-dihydroxypentan-2-one

Synonyms:[2-¹³C]-(3S,4R)-5-(benzyloxy)-3,4-dihydroxypentan-2-one

Suppliers and Price of [2-¹³C]-(3S,4R)-5-(benzyloxy)-3,4-dihydroxypentan-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [2-¹³C]-(3S,4R)-5-(benzyloxy)-3,4-dihydroxypentan-2-one

Chemical Property:

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Technology Process of [2-¹³C]-(3S,4R)-5-(benzyloxy)-3,4-dihydroxypentan-2-one

There total 4 articles about [2-¹³C]-(3S,4R)-5-(benzyloxy)-3,4-dihydroxypentan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1589493-99-1
[2-¹³C]-(E)-5-(benzyloxy)pent-3-en-2-one

: 1589494-00-7
[2-¹³C]-(3S,4R)-5-(benzyloxy)-3,4-dihydroxypentan-2-one

Guidance literature:: With potassium osmate(VI) dihydrate; methanesulfonamide; AD-mix β; sodium hydrogencarbonate; In water; toluene; tert-butyl alcohol; at 0 ℃; Inert atmosphere;
DOI:10.1039/c4cc00177j

Reference yield:

: 60656-87-3
benzyloxyacetoaldehyde

: 1589494-00-7
[2-¹³C]-(3S,4R)-5-(benzyloxy)-3,4-dihydroxypentan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: isopropylmagnesium chloride / tetrahydrofuran / -20 °C / Inert atmosphere

3.1: tetrahydrofuran; diethyl ether / 2 h / 0 - 20 °C / Inert atmosphere

4.1: potassium osmate(VI) dihydrate; sodium hydrogencarbonate; methanesulfonamide; AD-mix β / water; tert-butyl alcohol; toluene / 0 °C / Inert atmosphere

With potassium osmate(VI) dihydrate; methanesulfonamide; AD-mix β; isopropylmagnesium chloride; sodium hydride; sodium hydrogencarbonate; In tetrahydrofuran; diethyl ether; water; toluene; mineral oil; tert-butyl alcohol; 1.1: |Horner-Wadsworth-Emmons Olefination / 4.1: |Sharpless Dihydroxylation;
DOI:10.1039/c4cc00177j

Reference yield:

: 1589493-96-8
ethyl [1-¹³C]-(E)-4-(benzyloxy)but-2-enoate

: 1589494-00-7
[2-¹³C]-(3S,4R)-5-(benzyloxy)-3,4-dihydroxypentan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: isopropylmagnesium chloride / tetrahydrofuran / -20 °C / Inert atmosphere

2: tetrahydrofuran; diethyl ether / 2 h / 0 - 20 °C / Inert atmosphere

3: potassium osmate(VI) dihydrate; sodium hydrogencarbonate; methanesulfonamide; AD-mix β / water; tert-butyl alcohol; toluene / 0 °C / Inert atmosphere

With potassium osmate(VI) dihydrate; methanesulfonamide; AD-mix β; isopropylmagnesium chloride; sodium hydrogencarbonate; In tetrahydrofuran; diethyl ether; water; toluene; tert-butyl alcohol; 3: |Sharpless Dihydroxylation;
DOI:10.1039/c4cc00177j