benzyl 4-{3,3,3-trifluoro-2-[(methylsulfonyl)oxy]propoxy}piperidine-1-carboxylate

Base Information

Chemical Name:benzyl 4-{3,3,3-trifluoro-2-[(methylsulfonyl)oxy]propoxy}piperidine-1-carboxylate
CAS No.:1344684-83-8
Molecular Formula:C₁₇H₂₂F₃NO₆S
Molecular Weight:425.426
Hs Code.:

Synonyms:benzyl 4-{3,3,3-trifluoro-2-[(methylsulfonyl)oxy]propoxy}piperidine-1-carboxylate

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Chemical Property of benzyl 4-{3,3,3-trifluoro-2-[(methylsulfonyl)oxy]propoxy}piperidine-1-carboxylate

Chemical Property:

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Technology Process of benzyl 4-{3,3,3-trifluoro-2-[(methylsulfonyl)oxy]propoxy}piperidine-1-carboxylate

There total 3 articles about benzyl 4-{3,3,3-trifluoro-2-[(methylsulfonyl)oxy]propoxy}piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1344684-81-6
benzyl 4-(2-oxoethoxy)piperidine-1-carboxylate

: 1344684-83-8
benzyl 4-{3,3,3-trifluoro-2-[(methylsulfonyl)oxy]propoxy}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 73 h / 0 - 35 °C

1.2: 2 h / 0 °C

2.1: triethylamine / tetrahydrofuran / 0 - 35 °C

With tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran;

Reference yield:

: 4-ethoxycarbonylmethoxy-piperidine-1-carboxylic acid benzyl ester

: 1344684-83-8
benzyl 4-{3,3,3-trifluoro-2-[(methylsulfonyl)oxy]propoxy}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol; calcium chloride; sodium tetrahydroborate / tetrahydrofuran / 48 h / 0 - 35 °C

2.1: triethylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide / 1 h / 10 - 35 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 73 h / 0 - 35 °C

3.2: 2 h / 0 °C

4.1: triethylamine / tetrahydrofuran / 0 - 35 °C

With sodium tetrahydroborate; ethanol; tetrabutyl ammonium fluoride; sulfur trioxide pyridine complex; triethylamine; calcium chloride; In tetrahydrofuran; dimethyl sulfoxide;

Reference yield:

: 1235382-41-8
benzyl 4-(2-hydroxyethoxy)piperidine-1-carboxylate

: 1344684-83-8
benzyl 4-{3,3,3-trifluoro-2-[(methylsulfonyl)oxy]propoxy}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide / 1 h / 10 - 35 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 73 h / 0 - 35 °C

2.2: 2 h / 0 °C

3.1: triethylamine / tetrahydrofuran / 0 - 35 °C

With tetrabutyl ammonium fluoride; sulfur trioxide pyridine complex; triethylamine; In tetrahydrofuran; dimethyl sulfoxide;