N-((4S,6S)-4-(5-amino-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide

Base Information

Chemical Name:N-((4S,6S)-4-(5-amino-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide
CAS No.:1624605-58-8
Molecular Formula:C₁₉H₁₇F₄N₃O₂
Molecular Weight:395.356
Hs Code.:

Synonyms:N-((4S,6S)-4-(5-amino-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((4S,6S)-4-(5-amino-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide

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Technology Process of N-((4S,6S)-4-(5-amino-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide

There total 6 articles about N-((4S,6S)-4-(5-amino-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1624605-56-6
N-((4S,6S)-4-(5-bromo-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide

: 1624605-58-8
N-((4S,6S)-4-(5-amino-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide

Guidance literature:

Reference yield:

: 1624605-54-4
(S)-tert-butyl 3-(5-bromo-2-fluorophenyl)-3-((R)-1,1-dimethylethylsulfinamido)butanoate

: 1624605-58-8
N-((4S,6S)-4-(5-amino-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: lithium borohydride / tetrahydrofuran; ethyl acetate; methanol

2: ethyl acetate; dichloromethane

3: tetrabutyl ammonium fluoride / tetrahydrofuran; ethyl acetate

4: hydrogenchloride / 1,4-dioxane; dichloromethane; diethyl ether; hexane

5: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; ethyl acetate

With hydrogenchloride; lithium borohydride; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; hexane; dichloromethane; ethyl acetate;

Reference yield:

: (R)-N-((S)-2-(5-bromo-2-fluorophenyl)-4-hydroxybutan-2-yl)-2-methylpropane-2-sulfinamide

: 1624605-58-8
N-((4S,6S)-4-(5-amino-2-fluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: ethyl acetate; dichloromethane

2: tetrabutyl ammonium fluoride / tetrahydrofuran; ethyl acetate

3: hydrogenchloride / 1,4-dioxane; dichloromethane; diethyl ether; hexane

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; ethyl acetate

With hydrogenchloride; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; dichloromethane; ethyl acetate;