4'-[(2-butyl-6-nitro-1H-benzimidazol-1-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-[1,1'-biphenyl]-2-sulfonamide

Base Information

Chemical Name:4'-[(2-butyl-6-nitro-1H-benzimidazol-1-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-[1,1'-biphenyl]-2-sulfonamide
CAS No.:1393601-37-0
Molecular Formula:C₂₉H₂₉N₅O₅S
Molecular Weight:559.646
Hs Code.:

Synonyms:4'-[(2-butyl-6-nitro-1H-benzimidazol-1-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-[1,1'-biphenyl]-2-sulfonamide

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Chemical Property of 4'-[(2-butyl-6-nitro-1H-benzimidazol-1-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-[1,1'-biphenyl]-2-sulfonamide

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Technology Process of 4'-[(2-butyl-6-nitro-1H-benzimidazol-1-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-[1,1'-biphenyl]-2-sulfonamide

There total 6 articles about 4'-[(2-butyl-6-nitro-1H-benzimidazol-1-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-[1,1'-biphenyl]-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.6%

: 1393601-52-9
C₃₃H₃₇N₅O₇S

: 1393601-37-0
4'-[(2-butyl-6-nitro-1H-benzimidazol-1-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-[1,1'-biphenyl]-2-sulfonamide

Guidance literature:: With hydrogenchloride; water; In ethanol; for 2h; Reflux;
DOI:10.1016/j.bmc.2012.06.011

Reference yield:

: 19947-75-2
5-amino-3,4-dimethylisoxazol

: 1393601-37-0
4'-[(2-butyl-6-nitro-1H-benzimidazol-1-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-[1,1'-biphenyl]-2-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C / Inert atmosphere

2.2: 5 h / 0 - 20 °C

3.1: n-butyllithium; boric acid tributyl ester / tetrahydrofuran; toluene / -40 - -20 °C / Inert atmosphere

3.2: -20 - 20 °C

4.1: palladium diacetate; sodium carbonate; triphenylphosphine / propan-1-ol; water / 4 h / 20 °C / Inert atmosphere; Reflux

5.1: hydrogenchloride; water / ethanol / 2 h / Reflux

With pyridine; hydrogenchloride; n-butyllithium; boric acid tributyl ester; water; palladium diacetate; sodium hydride; sodium carbonate; triphenylphosphine; In tetrahydrofuran; propan-1-ol; ethanol; water; toluene; mineral oil;
DOI:10.1016/j.bmc.2012.06.011

Reference yield:

: 153623-86-0
N-(3,4-Dimethyl-5-isoxazolyl)-2-bromo-benzenesulfonamide

: 1393601-37-0
4'-[(2-butyl-6-nitro-1H-benzimidazol-1-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-[1,1'-biphenyl]-2-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C / Inert atmosphere

1.2: 5 h / 0 - 20 °C

2.1: n-butyllithium; boric acid tributyl ester / tetrahydrofuran; toluene / -40 - -20 °C / Inert atmosphere

2.2: -20 - 20 °C

3.1: palladium diacetate; sodium carbonate; triphenylphosphine / propan-1-ol; water / 4 h / 20 °C / Inert atmosphere; Reflux

4.1: hydrogenchloride; water / ethanol / 2 h / Reflux

With hydrogenchloride; n-butyllithium; boric acid tributyl ester; water; palladium diacetate; sodium hydride; sodium carbonate; triphenylphosphine; In tetrahydrofuran; propan-1-ol; ethanol; water; toluene; mineral oil;
DOI:10.1016/j.bmc.2012.06.011