4-Isopropoxy-3-[4-(2,3,5-trimethyl-3H-imidazol-4-yl)-thiazol-2-ylamino]-benzenesulfonamide

Base Information

• Chemical Name: 4-Isopropoxy-3-[4-(2,3,5-trimethyl-3H-imidazol-4-yl)-thiazol-2-ylamino]-benzenesulfonamide
• CAS No.: 1377837-66-5
• Molecular Formula: C₁₈H₂₃N₅O₃S₂
• Molecular Weight: 421.544
• Mol file: 1377837-66-5.mol

Synonyms:4-Isopropoxy-3-[4-(2,3,5-trimethyl-3H-imidazol-4-yl)-thiazol-2-ylamino]-benzenesulfonamide

Chemical Property of 4-Isopropoxy-3-[4-(2,3,5-trimethyl-3H-imidazol-4-yl)-thiazol-2-ylamino]-benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Isopropoxy-3-[4-(2,3,5-trimethyl-3H-imidazol-4-yl)-thiazol-2-ylamino]-benzenesulfonamide

There total 11 articles about 4-Isopropoxy-3-[4-(2,3,5-trimethyl-3H-imidazol-4-yl)-thiazol-2-ylamino]-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-isopropoxy-3-thioureido-benzenesulfonamide (1377582-43-8) + 2-bromo-1-(2,3,5-trimethyl-3H-imidazol-4-yl)-ethanone (1377837-88-1) → 4-Isopropoxy-3-[4-(2,3,5-trimethyl-3H-imidazol-4-yl)-thiazol-2-ylamino]-benzenesulfonamide (1377837-66-5)

Guidance literature:

In ethanol; at 20 ℃; for 24h;

Reference yield:

4-fluoro-3-nitrobenzenesulfonamide (406233-31-6) → 4-Isopropoxy-3-[4-(2,3,5-trimethyl-3H-imidazol-4-yl)-thiazol-2-ylamino]-benzenesulfonamide (1377837-66-5)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium / tetrahydrofuran / 6.17 h / 20 °C / Reflux

2: sodium tetrahydroborate; methanol; nickel(II) chloride hexahydrate / 0 - 23 °C

3: sodium hydrogencarbonate / chloroform; water / 1.5 h / 20 °C

4: ammonia / methanol / 18 h / 20 °C

5: ethanol / 24 h / 20 °C

With methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate; ammonia; sodium; sodium hydrogencarbonate; In tetrahydrofuran; methanol; ethanol; chloroform; water;

Reference yield:

1-(2,3,5-trimethyl-3H-imidazol-4-yl)-ethanone (403793-52-2) → 4-Isopropoxy-3-[4-(2,3,5-trimethyl-3H-imidazol-4-yl)-thiazol-2-ylamino]-benzenesulfonamide (1377837-66-5)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine; hydrogen bromide / water / 1.5 h / Heating

2: ethanol / 24 h / 20 °C

With hydrogen bromide; bromine; In ethanol; water;

upstream raw materials:

4-fluoro-3-nitrobenzenesulfonamide

1-(2,3,5-trimethyl-3H-imidazol-4-yl)-ethanone

1H-5-Acetyl-2,4-dimethylimidazole

1-(1-acetyl-2,5-dimethyl-1H-imidazol-4-yl)-ethanone