(R)-ethyl 1-((S)-1-nitro-4-phenylbut-3-yn-2-yl)-2-oxocyclopentanecarboxylate

Base Information

Chemical Name:(R)-ethyl 1-((S)-1-nitro-4-phenylbut-3-yn-2-yl)-2-oxocyclopentanecarboxylate
CAS No.:1432626-53-3
Molecular Formula:C₁₈H₁₉NO₅
Molecular Weight:329.353
Hs Code.:

Synonyms:(R)-ethyl 1-((S)-1-nitro-4-phenylbut-3-yn-2-yl)-2-oxocyclopentanecarboxylate

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Chemical Property of (R)-ethyl 1-((S)-1-nitro-4-phenylbut-3-yn-2-yl)-2-oxocyclopentanecarboxylate

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Technology Process of (R)-ethyl 1-((S)-1-nitro-4-phenylbut-3-yn-2-yl)-2-oxocyclopentanecarboxylate

There total 1 articles about (R)-ethyl 1-((S)-1-nitro-4-phenylbut-3-yn-2-yl)-2-oxocyclopentanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 52960-10-8
1-Nitro-4-phenyl-1-buten-3-in

: 611-10-9
2-ethoxycarbonyl-1-cyclopentanone

: 1432626-53-3
(R)-ethyl 1-((S)-1-nitro-4-phenylbut-3-yn-2-yl)-2-oxocyclopentanecarboxylate

Guidance literature:: With 1-((1R,2R)-2-(bis(3-phenylpropyl)amino)cyclohexyl)-3-(3,5-bis(trifluoromethyl)phenyl)thiourea; In diethyl ether; at -10 ℃; Reagent/catalyst; Solvent; enantioselective reaction;
DOI:10.1002/adsc.201200226

Reference yield:

: 1432626-53-3
(R)-ethyl 1-((S)-1-nitro-4-phenylbut-3-yn-2-yl)-2-oxocyclopentanecarboxylate

: 1432626-62-4
C₁₈H₁₉NO₂

Guidance literature:: (R)-ethyl 1-((S)-1-nitro-4-phenylbut-3-yn-2-yl)-2-oxocyclopentanecarboxylate; With zinc; In ethanol; at 35 ℃; for 0.166667h;

With hydrogenchloride; In ethanol; water; at 35 ℃; pH=0 - 1;
DOI:10.1002/adsc.201200226

Reference yield:

: 1432626-53-3
(R)-ethyl 1-((S)-1-nitro-4-phenylbut-3-yn-2-yl)-2-oxocyclopentanecarboxylate

: C₁₈H₂₁NO₂

: C₁₈H₂₁NO₂

Guidance literature:: Multi-step reaction with 2 steps

1.1: zinc / ethanol / 0.17 h / 35 °C

1.2: 35 °C / pH 0 - 1

2.1: acetic acid; sodium cyanoborohydride / acetonitrile / 24 h / 0 - 20 °C

With sodium cyanoborohydride; acetic acid; zinc; In ethanol; acetonitrile;
DOI:10.1002/adsc.201200226