(S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N-ethyl-4-methylpentanamide lithium

Base Information

Chemical Name:(S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N-ethyl-4-methylpentanamide lithium
CAS No.:1400929-63-6
Molecular Formula:C₁₇H₂₇N₃O₅P*Li
Molecular Weight:391.333
Hs Code.:

Synonyms:(S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N-ethyl-4-methylpentanamide lithium

Suppliers and Price of (S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N-ethyl-4-methylpentanamide lithium

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N-ethyl-4-methylpentanamide lithium

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of (S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N-ethyl-4-methylpentanamide lithium

There total 7 articles about (S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N-ethyl-4-methylpentanamide lithium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: N-(N-(benzyloxycarbonyl)-(R/S)-aminomethylphosphonyl)-N'-ethyl-L-leucinamide methyl ester

: 1400929-63-6
(S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N-ethyl-4-methylpentanamide lithium

Guidance literature:: With lithium hydroxide; In water; for 5h;
DOI:10.1021/jm401609a

Reference yield:

: 621-84-1
O-benzyl carbamate

: 1400929-63-6
(S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N-ethyl-4-methylpentanamide lithium

Guidance literature:: Multi-step reaction with 6 steps

1: sodium carbonate / water / 20 °C

2: pyridine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

3: 3 h / Reflux

4: sodium hydroxide / 2 h / 20 °C

5: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

6: lithium hydroxide / water / 2 h / 20 °C

With pyridine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm300472k

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 1400929-63-6
(S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N-ethyl-4-methylpentanamide lithium

Guidance literature:: Multi-step reaction with 4 steps

1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

2: hydrogenchloride / methanol / 20 °C

3: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

4: lithium hydroxide / water / 2 h / 20 °C

With hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm300472k