Technology Process of Pyrrolidine, 2,5-dipropyl-, (2R,5S)- (9CI)
There total 13 articles about Pyrrolidine, 2,5-dipropyl-, (2R,5S)- (9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
methanol;
for 24h;
under 2068.6 Torr;
Ambient temperature;
DOI:10.1016/S0040-4039(98)00134-8
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 1) (i-Bu)2AlH, 2) CuCl / 1) hexane, 2) THF
2: 61 percent / LiCl, p-benzoquinone / Pd(OAc)2 / pentane; acetic acid / 28 h / Ambient temperature
3: 62 percent / Cs2CO3 / dimethylformamide / 48 h / 50 °C
4: 95 percent / aqueous NaOH / methanol / 0.75 h / Heating
5: 99.5 percent / H2 / PtO2 / methanol / 3 h / 3800 Torr / Ambient temperature
6: 90 percent / triethylamine / tetrahydrofuran / 1) 0 deg C, 1.5 h, 2) RT, 1 h
7: K2CO3 / methanol / 3 h / Ambient temperature
8: sodium, liq. NH3
With
sodium hydroxide; ammonia; hydrogen; sodium; diisobutylaluminium hydride; potassium carbonate; caesium carbonate; triethylamine; p-benzoquinone; copper(l) chloride; lithium chloride;
platinum(IV) oxide; palladium diacetate;
In
tetrahydrofuran; methanol; acetic acid; N,N-dimethyl-formamide; pentane;
DOI:10.1021/jo00290a010
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 61 percent / LiCl, p-benzoquinone / Pd(OAc)2 / pentane; acetic acid / 28 h / Ambient temperature
2: 62 percent / Cs2CO3 / dimethylformamide / 48 h / 50 °C
3: 95 percent / aqueous NaOH / methanol / 0.75 h / Heating
4: 99.5 percent / H2 / PtO2 / methanol / 3 h / 3800 Torr / Ambient temperature
5: 90 percent / triethylamine / tetrahydrofuran / 1) 0 deg C, 1.5 h, 2) RT, 1 h
6: K2CO3 / methanol / 3 h / Ambient temperature
7: sodium, liq. NH3
With
sodium hydroxide; ammonia; hydrogen; sodium; potassium carbonate; caesium carbonate; triethylamine; p-benzoquinone; lithium chloride;
platinum(IV) oxide; palladium diacetate;
In
tetrahydrofuran; methanol; acetic acid; N,N-dimethyl-formamide; pentane;
DOI:10.1021/jo00290a010