benzyl 6-bromo-1-tert-butyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carboxylate

Base Information

Chemical Name:benzyl 6-bromo-1-tert-butyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carboxylate
CAS No.:1301214-86-7
Molecular Formula:C₂₃H₂₈BrN₃O₃
Molecular Weight:474.398
Hs Code.:

Synonyms:benzyl 6-bromo-1-tert-butyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carboxylate

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Chemical Property of benzyl 6-bromo-1-tert-butyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carboxylate

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Technology Process of benzyl 6-bromo-1-tert-butyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carboxylate

There total 3 articles about benzyl 6-bromo-1-tert-butyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1301214-85-6
benzyl 6-bromo-1-tert-butyl-7-hydroxy-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carboxylate

: 1301214-86-7
benzyl 6-bromo-1-tert-butyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carboxylate

Guidance literature:: benzyl 6-bromo-1-tert-butyl-7-hydroxy-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carboxylate; With Jones reagent; In acetone; at 20 ℃; Cooling with ice;

With sodium hydrogencarbonate; In water; acetone; pH=7;

Reference yield:

: 138163-08-3
N-(benzyloxycarbonyl)piperidine-4-carboxaldehyde

: 1301214-86-7
benzyl 6-bromo-1-tert-butyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene-4-sulfonic acid / benzene / 24 h / 70 °C / Reflux

1.2: 20 °C

2.1: toluene / 5 h / Reflux

3.1: acetic acid / ethanol / 1 h / Reflux

4.1: N-Bromosuccinimide; water / tetrahydrofuran / 1 h / 20 °C

5.1: Jones reagent / acetone / 20 °C / Cooling with ice

5.2: pH 7

With N-Bromosuccinimide; Jones reagent; water; acetic acid; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; acetone; toluene; benzene;

Reference yield:

: 1301214-81-2
8-(dimethylaminomethylene)-9-oxo-3-azaspiro[5.5]undec-10-ene-3-carboxylic acid benzyl ester

: 1301214-86-7
benzyl 6-bromo-1-tert-butyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / ethanol / 1 h / Reflux

2.1: N-Bromosuccinimide; water / tetrahydrofuran / 1 h / 20 °C

3.1: Jones reagent / acetone / 20 °C / Cooling with ice

3.2: pH 7

With N-Bromosuccinimide; Jones reagent; water; acetic acid; In tetrahydrofuran; ethanol; acetone;