Technology Process of N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-3-(4-methyl-1-piperazinyl)benzohydrazide
There total 11 articles about N'-(2-cyano-9-methyl-9H-purin-6-yI)-N'-cyclopentyl-3-(4-methyl-1-piperazinyl)benzohydrazide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium tert-butylate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran;
at 20 ℃;
for 24h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1,1'-bis-(diphenylphosphino)ferrocene; zinc / tris-(dibenzylideneacetone)dipalladium(0) / ISOPROPYLAMIDE / 0.05 h / 150 °C / 9000.9 Torr / Microwave irradiation
2: dowex D-50 (H+) / ethanol / 1 h / Heating / reflux
3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 0 °C
4: toluene-4-sulfonic acid / acetonitrile / 20 °C
5: potassium tert-butylate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 24 h / 20 °C
With
1,1'-bis-(diphenylphosphino)ferrocene; potassium tert-butylate; potassium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; zinc;
tris-(dibenzylideneacetone)dipalladium(0);
In
tetrahydrofuran; ethanol; ISOPROPYLAMIDE; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 15 h / Heating / reflux
2: 1,1'-bis-(diphenylphosphino)ferrocene; zinc / tris-(dibenzylideneacetone)dipalladium(0) / ISOPROPYLAMIDE / 0.05 h / 150 °C / 9000.9 Torr / Microwave irradiation
3: dowex D-50 (H+) / ethanol / 1 h / Heating / reflux
4: potassium carbonate / N,N-dimethyl-formamide / 2 h / 0 °C
5: toluene-4-sulfonic acid / acetonitrile / 20 °C
6: potassium tert-butylate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 24 h / 20 °C
With
1,1'-bis-(diphenylphosphino)ferrocene; potassium tert-butylate; potassium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; zinc;
tris-(dibenzylideneacetone)dipalladium(0);
In
tetrahydrofuran; ethanol; ISOPROPYLAMIDE; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;