(benzyloxycarbonyl)-L-valyl-N-<1-(cyanohydroxymethyl)-2-methylpropyl>-L-prolinamide

Base Information

Chemical Name:(benzyloxycarbonyl)-L-valyl-N-<1-(cyanohydroxymethyl)-2-methylpropyl>-L-prolinamide
CAS No.:120629-46-1
Molecular Formula:C₂₄H₃₄N₄O₅
Molecular Weight:458.558
Hs Code.:

Synonyms:(benzyloxycarbonyl)-L-valyl-N-<1-(cyanohydroxymethyl)-2-methylpropyl>-L-prolinamide

Suppliers and Price of (benzyloxycarbonyl)-L-valyl-N-<1-(cyanohydroxymethyl)-2-methylpropyl>-L-prolinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (benzyloxycarbonyl)-L-valyl-N-<1-(cyanohydroxymethyl)-2-methylpropyl>-L-prolinamide

Chemical Property:

Purity/Quality:

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Technology Process of (benzyloxycarbonyl)-L-valyl-N-<1-(cyanohydroxymethyl)-2-methylpropyl>-L-prolinamide

There total 1 articles about (benzyloxycarbonyl)-L-valyl-N-<1-(cyanohydroxymethyl)-2-methylpropyl>-L-prolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 151-50-8
potassium cyanide

: 95501-78-3
N-Benzyloxycarbonyl-L-valyl-L-prolyl-L-valinal

: 120629-46-1
(benzyloxycarbonyl)-L-valyl-N-<1-(cyanohydroxymethyl)-2-methylpropyl>-L-prolinamide

Guidance literature:: With water; In tetrahydrofuran; for 4.5h; Ambient temperature;
DOI:10.1021/ja00031a046

Reference yield:

: 120629-46-1
(benzyloxycarbonyl)-L-valyl-N-<1-(cyanohydroxymethyl)-2-methylpropyl>-L-prolinamide

: 138754-95-7,138811-26-4
(benzyloxycarbonyl)-L-valyl-N-<1-<(2-oxazolinyl)carbonyl>-2-methylpropyl>-L-prolinamide

Guidance literature:: Multi-step reaction with 3 steps

1: acetyl chloride / CHCl₃ / 16 h / Ambient temperature

2: 14 percent / triethylamine / CH₂Cl₂ / 16 h / Ambient temperature

3: 22 percent / oxalyl chloride, DMSO / CH₂Cl₂ / 1 h / -40 °C

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; acetyl chloride; In dichloromethane; chloroform;
DOI:10.1021/ja00031a046

Reference yield:

: 120629-46-1
(benzyloxycarbonyl)-L-valyl-N-<1-(cyanohydroxymethyl)-2-methylpropyl>-L-prolinamide

: 161443-20-5
(benzyloxycarbonyl)-L-valyl-N-<1-<(2-oxazolinyl)hydroxymethyl>-2-methylpropyl>-L-prolinamide

Guidance literature:: Multi-step reaction with 2 steps

1: acetyl chloride / CHCl₃ / 16 h / Ambient temperature

2: 14 percent / triethylamine / CH₂Cl₂ / 16 h / Ambient temperature

With triethylamine; acetyl chloride; In dichloromethane; chloroform;
DOI:10.1021/ja00031a046