(R)-3-(4-fluorophenyl)-3-methylcyclohexanone

Base Information

• Chemical Name: (R)-3-(4-fluorophenyl)-3-methylcyclohexanone
• CAS No.: 1189241-04-0
• Molecular Formula: C₁₃H₁₅FO
• Molecular Weight: 206.26
• Mol file: 1189241-04-0.mol

Synonyms:(R)-3-(4-fluorophenyl)-3-methylcyclohexanone

Chemical Property of (R)-3-(4-fluorophenyl)-3-methylcyclohexanone

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (R)-3-(4-fluorophenyl)-3-methylcyclohexanone

There total 3 articles about (R)-3-(4-fluorophenyl)-3-methylcyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-methylcyclohexen-2-one (1193-18-6) + tris(4-fluorophenyl)boroxine (448-59-9) → (R)-3-(4-fluorophenyl)-3-methylcyclohexanone (1189241-04-0)

Guidance literature:

3-methylcyclohexen-2-one; tris(4-fluorophenyl)boroxine; With 2C₂₄H₁₄F₄*2HO^(1-)*2Rh⁽¹⁺⁾; In 1,4-dioxane; at 60 ℃; for 24h; Inert atmosphere;

With water; In 1,4-dioxane; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1002/anie.201000467

Reference yield: 84.0%

3-methylcyclohexen-2-one (1193-18-6) + 4-fluoroboronic acid (1765-93-1) → (R)-3-(4-fluorophenyl)-3-methylcyclohexanone (1189241-04-0)

Guidance literature:

With palladium(II) trifluoroacetate; 2-[(S)-4,5-dihydro-4-tert-butyl-1,3-oxazol-2-yl]pyridine; In 1,2-dichloro-ethane; at 80 ℃; for 12h; optical yield given as %ee; enantioselective reaction;

DOI:10.1021/ja200664x

Reference yield:

3-methylcyclohexen-2-one (1193-18-6) + sodium tetrakis(4-fluorophenyl)borate (25776-12-9) → (R)-3-(4-fluorophenyl)-3-methylcyclohexanone (1189241-04-0) + C13H15FO (1392278-09-9)

Guidance literature:

With 2C₂₃H₂₄O₂*2Cl^(1-)*2Rh⁽¹⁺⁾; In tetrahydrofuran; at 60 ℃; for 60h; optical yield given as %ee; enantioselective reaction;

DOI:10.1021/ja905432x

upstream raw materials:

3-methylcyclohexen-2-one

sodium tetrakis(4-fluorophenyl)borate

tris(4-fluorophenyl)boroxine

4-fluoroboronic acid