(R)-4-{[4-(dimethylamino)-1-(phenylthio)but-2-yl]amino}-N-(4-ethynylphenyl)-3-nitrobenzenesulfonamide

Base Information

Chemical Name:(R)-4-{[4-(dimethylamino)-1-(phenylthio)but-2-yl]amino}-N-(4-ethynylphenyl)-3-nitrobenzenesulfonamide
CAS No.:1376191-26-2
Molecular Formula:C₂₆H₂₈N₄O₄S₂
Molecular Weight:524.665
Hs Code.:

Synonyms:(R)-4-{[4-(dimethylamino)-1-(phenylthio)but-2-yl]amino}-N-(4-ethynylphenyl)-3-nitrobenzenesulfonamide

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Chemical Property of (R)-4-{[4-(dimethylamino)-1-(phenylthio)but-2-yl]amino}-N-(4-ethynylphenyl)-3-nitrobenzenesulfonamide

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Technology Process of (R)-4-{[4-(dimethylamino)-1-(phenylthio)but-2-yl]amino}-N-(4-ethynylphenyl)-3-nitrobenzenesulfonamide

There total 4 articles about (R)-4-{[4-(dimethylamino)-1-(phenylthio)but-2-yl]amino}-N-(4-ethynylphenyl)-3-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 870812-32-1
(R)-N¹,N¹-dimethyl-4-(phenylthio)butane-1,3-diamine

: 6668-56-0
4-fluoro-3-nitrobenzene-1-sulfonyl chloride

: 14235-81-5
4-Ethynylaniline

: 1376191-26-2
(R)-4-{[4-(dimethylamino)-1-(phenylthio)but-2-yl]amino}-N-(4-ethynylphenyl)-3-nitrobenzenesulfonamide

Guidance literature:: 4-fluoro-3-nitrobenzene-1-sulfonyl chloride; 4-Ethynylaniline; With pyridine; Inert atmosphere;

(R)-N¹,N¹-dimethyl-4-(phenylthio)butane-1,3-diamine; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; Inert atmosphere;
DOI:10.1021/jm300178u

Reference yield:

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 1376191-26-2
(R)-4-{[4-(dimethylamino)-1-(phenylthio)but-2-yl]amino}-N-(4-ethynylphenyl)-3-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: chlorosulfonic acid

2: pyridine

3: N-ethyl-N,N-diisopropylamine

With pyridine; chlorosulfonic acid; N-ethyl-N,N-diisopropylamine;

Reference yield:

: 6668-56-0
4-fluoro-3-nitrobenzene-1-sulfonyl chloride

: 1376191-26-2
(R)-4-{[4-(dimethylamino)-1-(phenylthio)but-2-yl]amino}-N-(4-ethynylphenyl)-3-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine

2: N-ethyl-N,N-diisopropylamine

With pyridine; N-ethyl-N,N-diisopropylamine;