tert-butyl (4-(3-methyl-3-((2-nitrobenzyl)oxy)but-1-yn-1-yl)phenyl)carbamate

Base Information

• Chemical Name: tert-butyl (4-(3-methyl-3-((2-nitrobenzyl)oxy)but-1-yn-1-yl)phenyl)carbamate
• CAS No.: 1453814-00-0
• Molecular Formula: C₂₃H₂₆N₂O₅
• Molecular Weight: 410.47
• Mol file: 1453814-00-0.mol

Synonyms:tert-butyl (4-(3-methyl-3-((2-nitrobenzyl)oxy)but-1-yn-1-yl)phenyl)carbamate

Chemical Property of tert-butyl (4-(3-methyl-3-((2-nitrobenzyl)oxy)but-1-yn-1-yl)phenyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl (4-(3-methyl-3-((2-nitrobenzyl)oxy)but-1-yn-1-yl)phenyl)carbamate

There total 1 articles about tert-butyl (4-(3-methyl-3-((2-nitrobenzyl)oxy)but-1-yn-1-yl)phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

2-Nitrobenzyl alcohol (612-25-9) + tert-butyl (4-(3-hydroxy-3-methylbut-1-yn-1-yl)phenyl)carbamate (1453813-96-1) → tert-butyl (4-(3-methyl-3-((2-nitrobenzyl)oxy)but-1-yn-1-yl)phenyl)carbamate (1453814-00-0)

Guidance literature:

With copper(ll) bromide; In nitromethane; at 20 ℃; for 12h; Darkness;

DOI:10.1016/j.tetlet.2013.07.144

Reference yield: 90.0%

tert-butyl (4-(3-methyl-3-((2-nitrobenzyl)oxy)but-1-yn-1-yl)phenyl)carbamate (1453814-00-0) → tert-butyl (4-(3-hydroxy-3-methylbut-1-yn-1-yl)phenyl)carbamate (1453813-96-1)

Guidance literature:

In ethyl acetate; for 2h; UV-irradiation;

DOI:10.1016/j.tetlet.2013.07.144

Reference yield: 50.0%

tert-butyl (4-(3-methyl-3-((2-nitrobenzyl)oxy)but-1-yn-1-yl)phenyl)carbamate (1453814-00-0) → 4-Ethynylaniline (14235-81-5)

Guidance literature:

With potassium hydroxide; In toluene; at 110 ℃; for 10h; Inert atmosphere; UV-irradiation;

DOI:10.1016/j.tetlet.2013.07.144

upstream raw materials:

2-Nitrobenzyl alcohol

tert-butyl (4-(3-hydroxy-3-methylbut-1-yn-1-yl)phenyl)carbamate

Downstream raw materials:

tert-butyl (4-(3-hydroxy-3-methylbut-1-yn-1-yl)phenyl)carbamate

4-Ethynylaniline