(2R,3aS,6aR,10aS)-2-(tert-butyldiphenylsilanyloxymethyl)-9-[5-(tert-butyldiphenylsilanyloxy)pentyl]-10-oxo-1,2,4,6a,7,8,9,10-octahydro-3aH-3,9-diazacyclopenta[d]naphthalene-3,6-dicarboxylic acid 3-tert-butyl ester 6-methyl ester

Base Information

Chemical Name:(2R,3aS,6aR,10aS)-2-(tert-butyldiphenylsilanyloxymethyl)-9-[5-(tert-butyldiphenylsilanyloxy)pentyl]-10-oxo-1,2,4,6a,7,8,9,10-octahydro-3aH-3,9-diazacyclopenta[d]naphthalene-3,6-dicarboxylic acid 3-tert-butyl ester 6-methyl ester
CAS No.:221136-28-3
Molecular Formula:C₅₆H₇₄N₂O₇Si₂
Molecular Weight:943.384
Hs Code.:

(2R,3aS,6aR,10aS)-2-(tert-butyldiphenylsilanyloxymethyl)-9-[5-(tert-butyldiphenylsilanyloxy)pentyl]-10-oxo-1,2,4,6a,7,8,9,10-octahydro-3aH-3,9-diazacyclopenta[d]naphthalene-3,6-dicarboxylic acid 3-tert-butyl ester 6-methyl ester

Synonyms:(2R,3aS,6aR,10aS)-2-(tert-butyldiphenylsilanyloxymethyl)-9-[5-(tert-butyldiphenylsilanyloxy)pentyl]-10-oxo-1,2,4,6a,7,8,9,10-octahydro-3aH-3,9-diazacyclopenta[d]naphthalene-3,6-dicarboxylic acid 3-tert-butyl ester 6-methyl ester

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Chemical Property of (2R,3aS,6aR,10aS)-2-(tert-butyldiphenylsilanyloxymethyl)-9-[5-(tert-butyldiphenylsilanyloxy)pentyl]-10-oxo-1,2,4,6a,7,8,9,10-octahydro-3aH-3,9-diazacyclopenta[d]naphthalene-3,6-dicarboxylic acid 3-tert-butyl ester 6-methyl ester

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Technology Process of (2R,3aS,6aR,10aS)-2-(tert-butyldiphenylsilanyloxymethyl)-9-[5-(tert-butyldiphenylsilanyloxy)pentyl]-10-oxo-1,2,4,6a,7,8,9,10-octahydro-3aH-3,9-diazacyclopenta[d]naphthalene-3,6-dicarboxylic acid 3-tert-butyl ester 6-methyl ester

There total 9 articles about (2R,3aS,6aR,10aS)-2-(tert-butyldiphenylsilanyloxymethyl)-9-[5-(tert-butyldiphenylsilanyloxy)pentyl]-10-oxo-1,2,4,6a,7,8,9,10-octahydro-3aH-3,9-diazacyclopenta[d]naphthalene-3,6-dicarboxylic acid 3-tert-butyl ester 6-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 45152-58-7
tri-tert-butyl(ethenyl)stannane

: 221136-22-7
(2S)-4-{(Z-4-bromo-4-methoxycarbonylbut-3-enyl)-[5-(tert-butyldiphenylsilanyloxy)pentyl]carbamoyl}-2-(tert-butyldiphenylsilanyloxymethyl)-2,3-dihydropyrrole-1-carboxylic acid tert-butyl ester

: 221136-28-3
(2R,3aS,6aR,10aS)-2-(tert-butyldiphenylsilanyloxymethyl)-9-[5-(tert-butyldiphenylsilanyloxy)pentyl]-10-oxo-1,2,4,6a,7,8,9,10-octahydro-3aH-3,9-diazacyclopenta[d]naphthalene-3,6-dicarboxylic acid 3-tert-butyl ester 6-methyl ester

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; Heating;
DOI:10.1021/ja9829259

Reference yield: 68.0%

: 7486-35-3
tri-n-butyl(vinyl)tin

: 221136-22-7
(2S)-4-{(Z-4-bromo-4-methoxycarbonylbut-3-enyl)-[5-(tert-butyldiphenylsilanyloxy)pentyl]carbamoyl}-2-(tert-butyldiphenylsilanyloxymethyl)-2,3-dihydropyrrole-1-carboxylic acid tert-butyl ester

: 221136-28-3
(2R,3aS,6aR,10aS)-2-(tert-butyldiphenylsilanyloxymethyl)-9-[5-(tert-butyldiphenylsilanyloxy)pentyl]-10-oxo-1,2,4,6a,7,8,9,10-octahydro-3aH-3,9-diazacyclopenta[d]naphthalene-3,6-dicarboxylic acid 3-tert-butyl ester 6-methyl ester

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; for 30h; Heating;
DOI:10.1021/ja0202964

Reference yield:

: (5R)-5-(tert-butyldiphenylsilanyloxymethyl)-2-hydroxypyrrolidine-1-carboxylic acid tert-butyl ester 3-sodium carboxylate

: 221136-28-3
(2R,3aS,6aR,10aS)-2-(tert-butyldiphenylsilanyloxymethyl)-9-[5-(tert-butyldiphenylsilanyloxy)pentyl]-10-oxo-1,2,4,6a,7,8,9,10-octahydro-3aH-3,9-diazacyclopenta[d]naphthalene-3,6-dicarboxylic acid 3-tert-butyl ester 6-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl chloride / benzene / 0.25 h / 0 °C

1.2: 79 percent / Et₃N / CH₂Cl₂ / 0 °C

2.1: 68 percent / tetrakistriphenylphosphine palladium / toluene / 30 h / Heating

With oxalyl dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; benzene;
DOI:10.1021/ja0202964