2-Hydroxymethyl-cyclopentanecarboxylic acid ((R)-2-hydroxy-1-phenyl-ethyl)-amide

Base Information

Chemical Name:2-Hydroxymethyl-cyclopentanecarboxylic acid ((R)-2-hydroxy-1-phenyl-ethyl)-amide
CAS No.:86331-50-2
Molecular Formula:C₁₅H₂₁NO₃
Molecular Weight:263.337
Hs Code.:

Synonyms:2-Hydroxymethyl-cyclopentanecarboxylic acid ((R)-2-hydroxy-1-phenyl-ethyl)-amide

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Chemical Property of 2-Hydroxymethyl-cyclopentanecarboxylic acid ((R)-2-hydroxy-1-phenyl-ethyl)-amide

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Technology Process of 2-Hydroxymethyl-cyclopentanecarboxylic acid ((R)-2-hydroxy-1-phenyl-ethyl)-amide

There total 6 articles about 2-Hydroxymethyl-cyclopentanecarboxylic acid ((R)-2-hydroxy-1-phenyl-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 86331-45-5,95462-61-6
3-Hydroxy-2-((R)-2-hydroxy-1-phenyl-ethyl)-hexahydro-cyclopenta[c]pyrrol-1-one

: 86331-50-2
2-Hydroxymethyl-cyclopentanecarboxylic acid ((R)-2-hydroxy-1-phenyl-ethyl)-amide

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 50 ℃; for 4h;
DOI:10.1246/cl.1983.385

Reference yield:

: 56613-80-0
D-2-phenylglycinol

: 86331-50-2
2-Hydroxymethyl-cyclopentanecarboxylic acid ((R)-2-hydroxy-1-phenyl-ethyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 1.) 0 deg C, 15 min; 2.) r.t., 1 h

2: sodium acetate / 3 h / 100 °C

3: 1 N HCl in MeOH / 2 h / Heating

4: 94 percent / NaAlH₂(OCH₂CH₂OCH₃)2 / toluene / 4 h / -78 °C

5: 96 percent / NaBH₄ / aq. ethanol / 4 h / 50 °C

With hydrogenchloride; sodium tetrahydroborate; sodium acetate; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; ethanol; toluene;
DOI:10.1246/cl.1983.385

Reference yield:

: 86331-31-9
2-((R)-2-Hydroxy-1-phenyl-ethyl)-tetrahydro-cyclopenta[c]pyrrole-1,3-dione

: 86331-50-2
2-Hydroxymethyl-cyclopentanecarboxylic acid ((R)-2-hydroxy-1-phenyl-ethyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / NaAlH₂(OCH₂CH₂OCH₃)2 / toluene / 4 h / -78 °C

2: 96 percent / NaBH₄ / aq. ethanol / 4 h / 50 °C

With sodium tetrahydroborate; sodium bis(2-methoxyethoxy)aluminium dihydride; In ethanol; toluene;
DOI:10.1246/cl.1983.385