(2-{[(methylsulfanyl)methyl]sulfanyl}pyridin-3-yl)(phenyl)methanone

Base Information

• Chemical Name: (2-{[(methylsulfanyl)methyl]sulfanyl}pyridin-3-yl)(phenyl)methanone
• CAS No.: 1436852-54-8
• Molecular Formula: C₁₄H₁₃NOS₂
• Molecular Weight: 275.395
• Mol file: 1436852-54-8.mol

Synonyms:(2-{[(methylsulfanyl)methyl]sulfanyl}pyridin-3-yl)(phenyl)methanone

Chemical Property of (2-{[(methylsulfanyl)methyl]sulfanyl}pyridin-3-yl)(phenyl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-{[(methylsulfanyl)methyl]sulfanyl}pyridin-3-yl)(phenyl)methanone

There total 1 articles about (2-{[(methylsulfanyl)methyl]sulfanyl}pyridin-3-yl)(phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

formaldehyde methyldithiohemiacetal (29414-47-9) + (2-bromopyridin-3-yl)(phenyl)methanone (80100-13-6) → (2-{[(methylsulfanyl)methyl]sulfanyl}pyridin-3-yl)(phenyl)methanone (1436852-54-8)

Guidance literature:

With sodiumsulfide nonahydrate; In N,N-dimethyl-formamide; at 70 ℃;

DOI:10.1002/hlca.201200123

Reference yield:

(2-{[(methylsulfanyl)methyl]sulfanyl}pyridin-3-yl)(phenyl)methanone (1436852-54-8) → C14H13NOS2

Guidance literature:

With lithium diisopropyl amide; In 1,2-dimethoxyethane; at -78 - 0 ℃; for 0.5h;

DOI:10.1002/hlca.201200123

Reference yield:

(2-{[(methylsulfanyl)methyl]sulfanyl}pyridin-3-yl)(phenyl)methanone (1436852-54-8) → 2-(methylsulfanyl)-3-phenylthieno[2,3-b]pyridine (1436852-67-3)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium diisopropyl amide / 1,2-dimethoxyethane / 0.5 h / -78 - 0 °C

2: thionyl chloride; pyridine / tetrahydrofuran / 1 h / 0 - 20 °C

With pyridine; thionyl chloride; lithium diisopropyl amide; In tetrahydrofuran; 1,2-dimethoxyethane;

DOI:10.1002/hlca.201200123

upstream raw materials:

formaldehyde methyldithiohemiacetal

(2-bromopyridin-3-yl)(phenyl)methanone

Downstream raw materials:

2-(methylsulfanyl)-3-phenylthieno[2,3-b]pyridine