(2R,3R)-3-(di(ethoxycarbonyl)methyl)-2-benzyl-4,4,4-trifluorobutanoic acid

Base Information

• Chemical Name: (2R,3R)-3-(di(ethoxycarbonyl)methyl)-2-benzyl-4,4,4-trifluorobutanoic acid
• CAS No.: 1246956-37-5
• Molecular Formula: C₁₈H₂₁F₃O₆
• Molecular Weight: 390.356

Synonyms:(2R,3R)-3-(di(ethoxycarbonyl)methyl)-2-benzyl-4,4,4-trifluorobutanoic acid

Chemical Property of (2R,3R)-3-(di(ethoxycarbonyl)methyl)-2-benzyl-4,4,4-trifluorobutanoic acid

Chemical Property:

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Technology Process of (2R,3R)-3-(di(ethoxycarbonyl)methyl)-2-benzyl-4,4,4-trifluorobutanoic acid

There total 1 articles about (2R,3R)-3-(di(ethoxycarbonyl)methyl)-2-benzyl-4,4,4-trifluorobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl 2-(1,1,1-trifluoro-3-formyl-4-phenylbutan-2-yl)malonate → 3-(di(ethoxycarbonyl)methyl)-2-benzyl-4,4,4-trifluorobutanoic acid + (2R,3R)-3-(di(ethoxycarbonyl)methyl)-2-benzyl-4,4,4-trifluorobutanoic acid (1246956-37-5)

Guidance literature:

With sodium chlorite; potassium dihydrogenphosphate; dihydrogen peroxide; In methanol; water; acetonitrile; at 0 - 20 ℃; optical yield given as %ee;

DOI:10.1021/ol101894h

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