1-[2-bromo-4-[2-(3,5-dichlorophenyl)-2-(trifluoromethyl)-3H-thiophen-4-yl]phenyl]sulfanyl-Ν,Ν-diethyl-methanesulfonamide

Base Information

Chemical Name:1-[2-bromo-4-[2-(3,5-dichlorophenyl)-2-(trifluoromethyl)-3H-thiophen-4-yl]phenyl]sulfanyl-Ν,Ν-diethyl-methanesulfonamide
CAS No.:1610608-78-0
Molecular Formula:C₂₂H₂₁BrCl₂F₃NO₂S₃
Molecular Weight:635.417
Hs Code.:

Synonyms:1-[2-bromo-4-[2-(3,5-dichlorophenyl)-2-(trifluoromethyl)-3H-thiophen-4-yl]phenyl]sulfanyl-Ν,Ν-diethyl-methanesulfonamide

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Chemical Property of 1-[2-bromo-4-[2-(3,5-dichlorophenyl)-2-(trifluoromethyl)-3H-thiophen-4-yl]phenyl]sulfanyl-Ν,Ν-diethyl-methanesulfonamide

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Technology Process of 1-[2-bromo-4-[2-(3,5-dichlorophenyl)-2-(trifluoromethyl)-3H-thiophen-4-yl]phenyl]sulfanyl-Ν,Ν-diethyl-methanesulfonamide

There total 6 articles about 1-[2-bromo-4-[2-(3,5-dichlorophenyl)-2-(trifluoromethyl)-3H-thiophen-4-yl]phenyl]sulfanyl-Ν,Ν-diethyl-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56401-81-1
1-chloro-N,N-diethyl-methanesulfonamide

: 1610609-39-6
4-(3-bromo-4-tert-butylsulfanyl-phenyl)-2-(3,5-dichlorophenyl)-2-(trifluoromethyl)-3H-thiophene

: 1610608-78-0
1-[2-bromo-4-[2-(3,5-dichlorophenyl)-2-(trifluoromethyl)-3H-thiophen-4-yl]phenyl]sulfanyl-Ν,Ν-diethyl-methanesulfonamide

Guidance literature:: 4-(3-bromo-4-tert-butylsulfanyl-phenyl)-2-(3,5-dichlorophenyl)-2-(trifluoromethyl)-3H-thiophene; With sodium tetrahydroborate; potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h; Inert atmosphere;

1-chloro-N,N-diethyl-methanesulfonamide; In N,N-dimethyl-formamide; at 90 ℃; for 4h; Inert atmosphere;

Reference yield:

: 1610609-40-9
(Z)-1-(3-bromo-4-tert-butylsulfanyl-phenyl)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-but-2-en-1-one

: 1610608-78-0
1-[2-bromo-4-[2-(3,5-dichlorophenyl)-2-(trifluoromethyl)-3H-thiophen-4-yl]phenyl]sulfanyl-Ν,Ν-diethyl-methanesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere

2.1: lithium hydroxide / water; tetrahydrofuran / 20 °C

3.1: pyridine; methanesulfonyl chloride / 0 - 20 °C

4.1: pyridine; methanesulfonyl chloride / N,N-dimethyl-formamide / 2 h / 100 °C

5.1: boron tribromide / dichloromethane / 2 h / 0 °C

6.1: sodium tetrahydroborate; potassium carbonate / N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere

6.2: 4 h / 90 °C / Inert atmosphere

With pyridine; sodium tetrahydroborate; boron tribromide; potassium carbonate; methanesulfonyl chloride; triethylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1610609-35-2
ethyl 3-(3-bromo-4-tert-butylsulfanyl-phenyl)-5-(3,5-dichlorophenyl)-3-hydroxy-5-(trifluoromethyl)tetrahydrothiophene-2-carboxylate

: 1610608-78-0
1-[2-bromo-4-[2-(3,5-dichlorophenyl)-2-(trifluoromethyl)-3H-thiophen-4-yl]phenyl]sulfanyl-Ν,Ν-diethyl-methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hydroxide / water; tetrahydrofuran / 20 °C

2.1: pyridine; methanesulfonyl chloride / 0 - 20 °C

3.1: pyridine; methanesulfonyl chloride / N,N-dimethyl-formamide / 2 h / 100 °C

4.1: boron tribromide / dichloromethane / 2 h / 0 °C

5.1: sodium tetrahydroborate; potassium carbonate / N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere

5.2: 4 h / 90 °C / Inert atmosphere

With pyridine; sodium tetrahydroborate; boron tribromide; potassium carbonate; methanesulfonyl chloride; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;